概述

  • 产品名称Anti-Interferon gamma抗体[XMG1.2]
    参阅全部 Interferon gamma 一抗
  • 描述
    大鼠单克隆抗体[XMG1.2] to Interferon gamma
  • 经测试应用适用于: Flow Cyt, ELISAmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    E. coli expressed, recombinant mouse IFN gamma.

性能

应用

Our Abpromise guarantee covers the use of ab23637 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt
ELISA
  • 应用说明ELISA: Use at an assay dependent dilution.
    Flow Cyt: Membrane permeablisation is required for this application. Use at an assay dependent dilution.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
    • 组织特异性Released primarily from activated T lymphocytes.
    • 疾病相关In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.
    • 序列相似性Belongs to the type II (or gamma) interferon family.
    • 翻译后修饰Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
    • 细胞定位Secreted.
    • Information by UniProt
    • 数据库链接
    • 别名
      • IFG antibody
      • IFI antibody
      • IFN gamma antibody
      • IFN, immune antibody
      • IFN-gamma antibody
      • IFNG antibody
      • IFNG_HUMAN antibody
      • Immune interferon antibody
      • Interferon gamma antibody
      see all

    Anti-Interferon gamma antibody [XMG1.2] (ab23637)参考文献

    This product has been referenced in:
    • Hsieh B  et al. In vivo cytokine production in murine listeriosis. Evidence for immunoregulation by gamma delta+ T cells. J Immunol 156:232-7 (1996). Read more (PubMed: 8598467) »
    • Cherwinski HM  et al. Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies. J Exp Med 166:1229-44 (1987). Read more (PubMed: 2960769) »

    See all 2 Publications for this product

    Product Wall

    There are currently no Abreviews or Questions for ab23637.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"