Anti-Interferon gamma抗体[MD-1] (Biotin) (ab25017)

概述

  • 产品名称Anti-Interferon gamma抗体[MD-1] (Biotin)
    参阅全部 Interferon gamma 一抗
  • 描述
    小鼠单克隆抗体[MD-1] to Interferon gamma (Biotin)
  • 偶联物Biotin
  • 特异性This antibody does not detect human Interferon alpha or beta.
  • 经测试应用适用于: ELISA, Flow Cytmore details
  • 种属反应性
    与反应: Human, Macaque Monkey
    不与反应: Mouse, Rat
  • 免疫原

    Recombinant full length protein (Human)

  • 常规说明

    Conjugated with Biotin-7-NHS (N-hydroxysuccinimide).

性能

应用

Our Abpromise guarantee covers the use of ab25017 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent concentration.
Flow Cyt Use at an assay dependent concentration. ab18434-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

靶标

  • 功能Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
  • 组织特异性Released primarily from activated T lymphocytes.
  • 疾病相关In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.
  • 序列相似性Belongs to the type II (or gamma) interferon family.
  • 翻译后修饰Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • IFG antibody
    • IFI antibody
    • IFN gamma antibody
    • IFN, immune antibody
    • IFN-gamma antibody
    • IFNG antibody
    • IFNG_HUMAN antibody
    • Immune interferon antibody
    • Interferon gamma antibody
    see all

Anti-Interferon gamma antibody [MD-1] (Biotin) (ab25017)参考文献

This product has been referenced in:
  • Hadidi S  et al. Antisense deoxyoligonucleotides or antibodies to murine MD-1 inhibit rejection of allogeneic and xenogeneic skin grafts in C3H mice. Transplantation 73:1771-9 (2002). Read more (PubMed: 12085000) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab25017.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"