Anti-Interferon gamma抗体[GIF-10] (ab9805)

概述

性能

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应用

Our Abpromise guarantee covers the use of ab9805 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Sandwich ELISA Use at an assay dependent dilution. Can be paired for Sandwich ELISA with Mouse monoclonal [GIF-3] to Interferon gamma (ab9801). PubMed: 9458493Use as capture antibody with recommended pair. sELISA can be used to determine IFN-g concentration in the cultures of human peripheral blood mononuclear cells.
Indirect ELISA Use at an assay dependent dilution.
WB Use at an assay dependent dilution.

靶标

  • 功能Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
  • 组织特异性Released primarily from activated T lymphocytes.
  • 疾病相关In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.
  • 序列相似性Belongs to the type II (or gamma) interferon family.
  • 翻译后修饰Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • IFG antibody
    • IFI antibody
    • IFN gamma antibody
    • IFN, immune antibody
    • IFN-gamma antibody
    • IFNG antibody
    • IFNG_HUMAN antibody
    • Immune interferon antibody
    • Interferon gamma antibody
    see all

Anti-Interferon gamma antibody [GIF-10] (ab9805)参考文献

This product has been referenced in:
  • Osna N  et al. Serum of patients with Guillain-Barre syndrome modulates mitogen-induced cytokine synthesis by normal peripheral blood mononuclear cells. Centr. Eur. J. Immun. 24:82-87 (1999). Read more (PubMed: ) »
  • Poluektova L  et al. Immunoregulatory effects of N9-benzyl- and N7-benzyl-8-bromoguanines. Int J Immunopharmacol 21:777-92 (1999). Read more (PubMed: 10576622) »

See all 4 Publications for this product

Product Wall

Yes, antibodies of clones GIF3 and GIF-10 have been used in a sandwich ELISA. The sensitivity of the assay is 300 pg/ml. For the sandwich ELISA, antibody GIF-3 was labelled with biotin. Specific reference for this is Osna N et al. Chronic hepatitis C...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"