Anti-Interferon gamma抗体[F12] (ab8096)

概述

  • 产品名称Anti-Interferon gamma抗体[F12]
    参阅全部 Interferon gamma 一抗
  • 描述
    小鼠单克隆抗体[F12] to Interferon gamma
  • 特异性Monoclonal antibody F14 binds and neutralizes both natural and recombinant human gamma Interferon. Cross-reactivity with other cytokines has not been found. In general, monoclonal antibodies to gamma Interferon are able to inhibit Shwartzman reactions (reviewed by A. Billiau, 1988) and in the murine system appear to protect NZB mice against spontaneous development of autoimmune disease (Jacob et el., 1987).
  • 经测试应用适用于: ELISA, IHC-Fr, Neutralising, IPmore details
  • 种属反应性
    与反应: Human
  • 常规说明One neutralizing unit is defined as the amount of antibody sufficient for neutralizing one unit of human gamma Interferon as calibrated against NIH standard Gg23-901-530. For the determination of the neutralizing activity a cytopathic inhibition assay was used.

性能

应用

Our Abpromise guarantee covers the use of ab8096 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.
Neutralising Use at an assay dependent concentration. Binds and neutralizes both natural and recombinant human gamma interferon.
IP Use at an assay dependent concentration.

靶标

  • 功能Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
  • 组织特异性Released primarily from activated T lymphocytes.
  • 疾病相关In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.
  • 序列相似性Belongs to the type II (or gamma) interferon family.
  • 翻译后修饰Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • IFG antibody
    • IFI antibody
    • IFN gamma antibody
    • IFN, immune antibody
    • IFN-gamma antibody
    • IFNG antibody
    • IFNG_HUMAN antibody
    • Immune interferon antibody
    • Interferon gamma antibody
    see all

Anti-Interferon gamma antibody [F12] (ab8096)参考文献

ab8096 has not yet been referenced specifically in any publications.

Product Wall

This antibody has only been tested in frozen sections, therefore we can't guarantee results.

The two monoclonals can be used in Elisa as a sandwich pair. However both antibodies contain BSA. This makes the antibodies unuseful as coating antibody. We suggest that you look at our complete optimised Elisa test kits: ab7440, ab7441, ab7442

No, we do not stock these IFN-gamma antibodies

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"