Anti-Interferon gamma抗体[F1] (ab11855)

概述

  • 产品名称Anti-Interferon gamma抗体[F1]
    参阅全部 Interferon gamma 一抗
  • 描述
    大鼠单克隆抗体[F1] to Interferon gamma
  • 经测试应用适用于: Purification, IPmore details
    不适用于: Neut
  • 种属反应性
    与反应: Mouse
    不与反应: Rat, Human
  • 免疫原

    Recombinant full length protein (Mouse).

  • 常规说明Possible applications include the purification of human gamma interferon. In general, monoclonal antibodies to gamma interferon are able to inhibit Shwartzman reactions and in the murine system appear to protect NZB mice against spontaneous development of autoimmune disease.

性能

应用

Our Abpromise guarantee covers the use of ab11855 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Purification
IP
  • 应用说明IP: Use at an assay dependent dilution.
    Purification: Use at an assay dependent dilution.

    Is unsuitable for Neutralization.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
    • 组织特异性Released primarily from activated T lymphocytes.
    • 疾病相关In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.
    • 序列相似性Belongs to the type II (or gamma) interferon family.
    • 翻译后修饰Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
    • 细胞定位Secreted.
    • Information by UniProt
    • 数据库链接
    • 别名
      • IFG antibody
      • IFI antibody
      • IFN gamma antibody
      • IFN, immune antibody
      • IFN-gamma antibody
      • IFNG antibody
      • IFNG_HUMAN antibody
      • Immune interferon antibody
      • Interferon gamma antibody
      see all

    Anti-Interferon gamma antibody [F1] (ab11855)参考文献

    ab11855 has not yet been referenced specifically in any publications.

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