概述
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产品名称Anti-Interferon gamma抗体[F-3]
参阅全部 Interferon gamma 一抗 -
描述大鼠单克隆抗体[F-3] to Interferon gamma
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特异性This antibody binds and neutralizes both natural and recombinant mouse gamma Interferon.
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经测试应用适用于: IP, Inhibition Assaymore details
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种属反应性与反应: Mouse
性能
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形式Liquid
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存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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存储溶液PBS with 0.1% sodium azide
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Concentration information loading... -
纯度IgG fraction
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克隆单克隆
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克隆编号F-3
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同种型IgG2a
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研究领域
相关产品
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Compatible Secondaries
应用
Our Abpromise guarantee covers the use of ab7372 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IP | Use at an assay dependent dilution. | |
| Inhibition Assay | Use at an assay dependent dilution. inhibits the activity of IFN gamma both in vivo and in vitro. |
靶标
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功能Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
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组织特异性Released primarily from activated T lymphocytes.
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疾病相关In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.
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序列相似性Belongs to the type II (or gamma) interferon family.
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翻译后修饰Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
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细胞定位Secreted.
- Information by UniProt
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数据库链接
- Entrez Gene: 15978 Mouse
- SwissProt: P01580 Mouse
- Unigene: 240327 Mouse
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别名
- IFG antibody
- IFI antibody
- IFN gamma antibody
see all
Anti-Interferon gamma antibody [F-3] (ab7372)参考文献
ab7372 has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"