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功能
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
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组织特异性
Released primarily from activated T lymphocytes.
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疾病相关
In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.
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序列相似性
Belongs to the type II (or gamma) interferon family.
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翻译后修饰
Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
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细胞定位
Secreted.
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Information by UniProt
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数据库链接
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别名
- IFG antibody
- IFI antibody
- IFN gamma antibody
- IFN, immune antibody
- IFN-gamma antibody
- IFNG antibody
- IFNG_HUMAN antibody
- Immune interferon antibody
- Interferon gamma antibody
see all