Anti-Interferon gamma抗体[DB-1] (ab22543)

概述

  • 产品名称Anti-Interferon gamma抗体[DB-1]
    参阅全部 Interferon gamma 一抗
  • 描述
    小鼠单克隆抗体[DB-1] to Interferon gamma
  • 特异性This antibody reacts with both mouse and rat Interferon gamma. Clone DB-1 exhibits high affinity binding to the natural and recombinant forms and effectively neutralises the anti viral activity of IFN-gamma. It also blocks the induction of La antigen expression on murine keratinocytes.
  • 经测试应用适用于: ELISA, Blocking, Neutralisingmore details
  • 种属反应性
    与反应: Mouse, Rat
  • 免疫原

    Recombinant full length rat IFN gamma

性能

应用

Our Abpromise guarantee covers the use of ab22543 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA
Blocking
Neutralising
  • 应用说明BL: Use at an assay dependent dilution
    ELISA: Use at a concentration of 10 µg/ml, 100ul/well as coating antibody
    Neut: Use at an assay dependent dilution.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
    • 组织特异性Released primarily from activated T lymphocytes.
    • 疾病相关In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.
    • 序列相似性Belongs to the type II (or gamma) interferon family.
    • 翻译后修饰Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
    • 细胞定位Secreted.
    • Information by UniProt
    • 数据库链接
    • 别名
      • IFG antibody
      • IFI antibody
      • IFN gamma antibody
      • IFN, immune antibody
      • IFN-gamma antibody
      • IFNG antibody
      • IFNG_HUMAN antibody
      • Immune interferon antibody
      • Interferon gamma antibody
      see all

    Anti-Interferon gamma antibody [DB-1] (ab22543)参考文献

    ab22543 has not yet been referenced specifically in any publications.

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