Anti-Interferon gamma抗体[B27] (Biotin) (ab24950)

概述

  • 产品名称Anti-Interferon gamma抗体[B27] (Biotin)
    参阅全部 Interferon gamma 一抗
  • 描述
    小鼠单克隆抗体[B27] to Interferon gamma (Biotin)
  • 偶联物Biotin
  • 特异性ab24950 does not bind to denatured Interferon gamma.
  • 经测试应用适用于: Neutralising, ELISA, Flow Cyt, ICC/IF, IPmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length protein: E. coli expressed recombinant human interferon gamma.

性能

应用

Our Abpromise guarantee covers the use of ab24950 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Neutralising
ELISA
Flow Cyt
ICC/IF
IP
  • 应用说明ELISA: Use at an assay dependent dilution.
    Flow Cyt: Use at an assay dependent dilution.
    IF: Use at an assay dependent dilution.
    IP: Use at an assay dependent dilution.
    Neut: Use at an assay dependent dilution.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
    • 组织特异性Released primarily from activated T lymphocytes.
    • 疾病相关In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.
    • 序列相似性Belongs to the type II (or gamma) interferon family.
    • 翻译后修饰Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
    • 细胞定位Secreted.
    • Information by UniProt
    • 数据库链接
    • 别名
      • IFG antibody
      • IFI antibody
      • IFN gamma antibody
      • IFN, immune antibody
      • IFN-gamma antibody
      • IFNG antibody
      • IFNG_HUMAN antibody
      • Immune interferon antibody
      • Interferon gamma antibody
      see all

    Anti-Interferon gamma antibody [B27] (Biotin) (ab24950)参考文献

    This product has been referenced in:
    • Amara RR  et al. Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine. Science 292:69-74 (2001). Read more (PubMed: 11393868) »
    • Abrams JS  et al. Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples. Immunol Rev 127:5-24 (1992). Read more (PubMed: 1387110) »

    See all 3 Publications for this product

    Product Wall

    Thank you for contacting Abcam regarding ab24950.


    Regarding the expiration of this product, we expect the product to be stable for up to 1 year when stored at 4deg C.


    For storage we do not recommend further diluting the ...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"