Anti-Interferon gamma抗体(ab7740)

概述

  • 产品名称Anti-Interferon gamma抗体
    参阅全部 Interferon gamma 一抗
  • 描述
    兔多克隆抗体to Interferon gamma
  • 特异性The antibody reacts with rat IFN-g of both natural and recombinant origin. The antibody inhibits the biological activity of natural and recombinant rat IFN-g. The antigen specificity was further assessed by ELISA and western blot. No cross-reactivities with other cytokines have been detected.
  • 经测试应用适用于: IHC-Fr, Inhibition Assay, Neutralising, WBmore details
  • 种属反应性
    与反应: Rat

性能

应用

Our Abpromise guarantee covers the use of ab7740 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-Fr Use at an assay dependent concentration.
Inhibition Assay Use at an assay dependent concentration.
Neutralising Use at an assay dependent concentration.
WB Use at an assay dependent concentration.

靶标

  • 功能Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
  • 组织特异性Released primarily from activated T lymphocytes.
  • 疾病相关In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.
  • 序列相似性Belongs to the type II (or gamma) interferon family.
  • 翻译后修饰Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • IFG antibody
    • IFI antibody
    • IFN gamma antibody
    • IFN, immune antibody
    • IFN-gamma antibody
    • IFNG antibody
    • IFNG_HUMAN antibody
    • Immune interferon antibody
    • Interferon gamma antibody
    see all

Anti-Interferon gamma antibody (ab7740)参考文献

ab7740 has not yet been referenced specifically in any publications.

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