Anti-Interferon beta抗体[PBS-03] (ab6979)


  • 产品名称
    Anti-Interferon beta抗体[PBS-03]
    参阅全部 Interferon beta 一抗
  • 描述
    小鼠单克隆抗体[PBS-03] to Interferon beta
  • 宿主
  • 特异性
    This antibody is specific for beta interferon (both glycosylated and non-glycosylated forms). It does not recognise other interferons (alpha, gamma or omega).
  • 经测试应用
    适用于: WB, ELISA, Neutralisingmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant human interferon-beta (non-glycosylated)

  • 表位
    The epitope target is the AB loop, aa# 30-47 of IFN.
  • 常规说明

    Abcam is committed to meeting high standards of ethical manufacturing and has decided to discontinue this product by June 2019 as it has been generated by the ascites method. We are sorry for any inconvenience this may cause. We would recommend antibody ab176343 as a replacement.



Our Abpromise guarantee covers the use of ab6979 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent concentration.
ELISA Use at an assay dependent concentration.
Neutralising Use at an assay dependent concentration. Neutralizes IFN-b in antiviral bioassay.


  • 功能
    Has antiviral, antibacterial and anticancer activities.
  • 序列相似性
    Belongs to the alpha/beta interferon family.
  • 细胞定位
  • Information by UniProt
  • 数据库链接
  • 别名
    • beta-interferon antibody
    • Fibroblast interferon antibody
    • IFB antibody
    • IFF antibody
    • IFN beta antibody
    • IFN-beta antibody
    • IFNB 1 antibody
    • IFNB antibody
    • IFNB_HUMAN antibody
    • IFNB1 antibody
    • Interferon beta 1 fibroblast antibody
    • Interferon beta antibody
    • Interferon beta precursor antibody
    • MGC96956 antibody
    see all



This product has been referenced in:
  • Xie C  et al. Effects of IRF1 and IFN-ß interaction on the M1 polarization of macrophages and its antitumor function. Int J Mol Med 38:148-60 (2016). Read more (PubMed: 27176664) »
  • Li Z  et al. Critical roles of glucocorticoid-induced leucine zipper in infectious bursal disease virus (IBDV)-induced suppression of type I Interferon expression and enhancement of IBDV growth in host cells via interaction with VP4. J Virol 87:1221-31 (2013). Read more (PubMed: 23152515) »

See all 4 Publications for this product


Since this product does not come in a sterile system (like a capped vial filled in a GMP cleanroom) it can not be considered sterile nor free of any environmental trace contaminant including endotoxin.

Thank you for contacting us.

This epitope position description should be relative to aa #1 of the mature protein.

I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

We have not tested the beta interferon antibody ab6979 in a sandwich ELISA but we expect it will will be effective as a capture antibody when paired with a polyclonal antibody raised against full-length beta IFN for detection. For example, ab84258 is a...

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Thank you for contacting us.

I think these two antibodies will work together in a sandwich ELISA, but we have not tested them together. You will need to test a few different dilutions to achieve the optimal signal with the least background. ...

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Generally we screen plate types for any given ELISA and reagent set. For ab6979 most work is done on Immulon 4 plates. Other types should work, the choice usually depends on the choice of reagents used to reduce non-specific binding. Nunc plates also ...

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Thank you for your enquiry. There is no reason why this strategy wouldnt work provided ab6979 and ab10740 do not compete for the same epitope on Interferon beta (AB loop, aa# 30-47 of IFN). Unfortunately I do not have details of ab10740's epitope. ...

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The statement "The titer assigned to the product was 1.4 ug/ml against non-glycosylated IFNb and 2.7 ug/ml against glycosylated IFNb." indicates a different neutralization potential of the Mab against glycosylated (natural) vs. non-glycosylated (recomb...

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As stated on the datasheet we recommend a concentration of 5 µg/ml for WB. The MW of the target IFN-b depends on the source. The polypeptide itself is about 18-19 kDa but the mammalian cell product is glycosylated and would run a bit larger

For ab6979, neutralizing titer was determined in an A549 cell with EMC napthol blue black dye uptake assay (by the method of Grossberg et al. Manual of Clinical Immunology 1986, pg 295-299). The titer assigned was 1.4 ug/ml against non-glycosylated ...

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We do not currently have any data on the limits of detection of this antibody in ELISA.