Anti-Interferon alpha抗体(ab24767)

概述

  • 产品名称Anti-Interferon alpha抗体
    参阅全部 Interferon alpha 一抗
  • 描述
    兔多克隆抗体to Interferon alpha
  • 特异性Recognizes chicken Interferon alpha (chIFN-alpha). The antibody cross reacts with IFN beta but does not cross react with IFN gamma. This antibody will recognize chicken IFN beta by Western blotting; it does not neutralize its activity in vitro. It does, however, neutralize the activity of IFN alpha, and thus it can be used to distinguish the two bioactivities. Presumably it recognizes an epitope that is only revealed in IFN beta following denaturation.
  • 经测试应用适用于: ELISA, IP, WB, Functional Studiesmore details
  • 种属反应性
    与反应: Chicken
  • 免疫原

    Recombinant full length protein (Chicken)

  • 常规说明


    The classification of mammalian cytokines with antiviral activity, is well documented as being either Type I Interferon (IFNI) or Type II Interferon (IFNII). This is not the case for avian IFNs however, even though IFN was first detected in the chicken. A growing number of functional studies indicate similarities between chicken IFN and mammalian IFNI, revealing the conservation of cysteine residues and the existence of around ten closely related intron-less IFN alpha genes. Further research has shown that chIFN-alpha genes are strongly expressed following viral infection of monocyte-derived macrophage and embryo fibroblasts and that recombinant chicken IFN acts as a potent antiviral agent.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: None
  • Concentration information loading...
  • 纯度Protein G purified
  • Primary antibody说明The classification of mammalian cytokines with antiviral activity, is well documented as being either Type I Interferon (IFNI) or Type II Interferon (IFNII). This is not the case for avian IFNs however, even though IFN was first detected in the chicken. A growing number of functional studies indicate similarities between chicken IFN and mammalian IFNI, revealing the conservation of cysteine residues and the existence of around ten closely related intron-less IFN alpha genes. Further research has shown that chIFN-alpha genes are strongly expressed following viral infection of monocyte-derived macrophage and embryo fibroblasts and that recombinant chicken IFN acts as a potent antiviral agent.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab24767 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent dilution.
IP Use at an assay dependent dilution.
WB Use at an assay dependent dilution. Detects a band of approximately 19 kDa.
Functional Studies Use at an assay dependent dilution.

靶标

  • 功能Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
  • 序列相似性Belongs to the alpha/beta interferon family.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • IFL antibody
    • IFN alpha antibody
    • IFN alpha 1/13 antibody
    • IFN alpha 1b antibody
    • IFN alphaD antibody
    • IFN antibody
    • IFN-alpha-1/13 antibody
    • IFNA@ antibody
    • IFNA1 antibody
    • IFNA1_HUMAN antibody
    • IFNA13 antibody
    • Interferon alpha 1 antibody
    • Interferon alpha-1/13 antibody
    • Interferon alpha-D antibody
    • Interferon alpha1 antibody
    • Interferon, alpha 13 antibody
    • LeIF D antibody
    see all

Anti-Interferon alpha antibody (ab24767)参考文献

ab24767 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting us.  We do not test the concentration of the specific antibody in our protein G affinity purified antibodies. The 0.5 mg/mL concentration would correspond to total Ig. However, we expect >90% of the antibody to be specific in t...

Read More

Thank you for your inquiry. Generally with affinity purified IgG, we expect >90% specific antibody. We do not measure the specific IgG concentration for these affinity purified products, just total IgG. I hope this information is helpful.  Plea...

Read More

Thank you for your enquiry. The situation with this antibody is that while it will recognize chicken interferon beta by Western blotting, it does not neutralize its activity in vitro. It does, however, neutralize the activity of interferon alpha, and t...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"