Anti-Integrin beta 7抗体[FIB504] (Phycoerythrin) (ab95817)


  • 产品名称Anti-Integrin beta 7抗体[FIB504] (Phycoerythrin)
    参阅全部 Integrin beta 7 一抗
  • 描述
    大鼠单克隆抗体[FIB504] to Integrin beta 7 (Phycoerythrin)
  • 偶联物Phycoerythrin. Ex: 488nm, Em: 575nm
  • 经测试应用适用于: Flow Cytmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    TK1 murine t-cell lymphoma

  • 阳性对照
    • Normal Human peripheral blood cells
  • 常规说明1 test = 5 microlitres



Our Abpromise guarantee covers the use of ab95817 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use 5µl for 106 cells.


  • 功能Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.
  • 组织特异性Expressed in a variety of leukocyte lines.
  • 序列相似性Belongs to the integrin beta chain family.
    Contains 1 VWFA domain.
  • 结构域Domain I contains three cation-binding sites: the ligand-integrin-binding site (LIMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent to MIDAS site (ADMIDAS). In the absence of a ligand or in calcium-dependent binding, only ADMIDAS is occupied. In magnesium-dependent binding all three sites bind metal ions. LIMBS positively modify ligand binding whereas ADMIDAS negatively modify ligand binding.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Gut homing receptor beta subunit antibody
    • Integrin beta 7 subunit antibody
    • Integrin beta-7 antibody
    • Integrin beta-P antibody
    • Integrin, beta 7 antibody
    • ITB7 antibody
    • ITB7_HUMAN antibody
    • Itgb7 antibody
    • Ly69 antibody
    • M290 IEL antigen antibody
    see all

Anti-Integrin beta 7 antibody [FIB504] (Phycoerythrin) 图像

  • Staining of normal Human peripheral blood cells with Rat IgG2a ? Isotype Control PE (open histogram) or ab95817 (filled histogram). Cells in the lymphocyte gate were used for analysis.

Anti-Integrin beta 7 antibody [FIB504] (Phycoerythrin) (ab95817)参考文献

This product has been referenced in:
  • Meerschaert J  et al. Engagement of alpha4beta7 integrins by monoclonal antibodies or ligands enhances survival of human eosinophils in vitro. J Immunol 163:6217-27 (1999). Read more (PubMed: 10570314) »

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