RabMAb

Anti-Integrin beta 7抗体[EPR1357] (ab108926)

概述

  • 产品名称Anti-Integrin beta 7抗体[EPR1357]
    参阅全部 Integrin beta 7 一抗
  • 描述
    兔单克隆抗体[EPR1357] to Integrin beta 7
  • 经测试应用适用于: WB, ICCmore details
    不适用于: Flow Cyt,IHC-P or IP
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to residues in Human Integrin beta 7.

  • 阳性对照
    • Human peripheral blood mononuclear cell lysate, Human tonsil lystate, and THP-1 cell lysate
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    A trial size is available to purchase for this antibody.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

性能

应用

Our Abpromise guarantee covers the use of ab108926 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Predicted molecular weight: 87 kDa.
ICC 1/100 - 1/250.
  • 应用说明Is unsuitable for Flow Cyt,IHC-P or IP.
  • 靶标

    • 功能Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.
    • 组织特异性Expressed in a variety of leukocyte lines.
    • 序列相似性Belongs to the integrin beta chain family.
      Contains 1 VWFA domain.
    • 结构域Domain I contains three cation-binding sites: the ligand-integrin-binding site (LIMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent to MIDAS site (ADMIDAS). In the absence of a ligand or in calcium-dependent binding, only ADMIDAS is occupied. In magnesium-dependent binding all three sites bind metal ions. LIMBS positively modify ligand binding whereas ADMIDAS negatively modify ligand binding.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Gut homing receptor beta subunit antibody
      • Integrin beta 7 subunit antibody
      • Integrin beta-7 antibody
      • Integrin beta-P antibody
      • Integrin, beta 7 antibody
      • ITB7 antibody
      • ITB7_HUMAN antibody
      • Itgb7 antibody
      • Ly69 antibody
      • M290 IEL antigen antibody
      see all

    Anti-Integrin beta 7 antibody [EPR1357] 图像

    • All lanes : Anti-Integrin beta 7 antibody [EPR1357] (ab108926) at 1/1000 dilution

      Lane 1 : Human peripheral blood mononuclear lysate
      Lane 2 : Human tonsil lysate
      Lane 3 : THP-1 cell lysate

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 87 kDa

    Anti-Integrin beta 7 antibody [EPR1357] (ab108926)参考文献

    ab108926 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"