Anti-Integrin beta 7抗体(ab124223)

概述

  • 产品名称Anti-Integrin beta 7抗体
    参阅全部 Integrin beta 7 一抗
  • 描述
    兔多克隆抗体to Integrin beta 7
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region withn C terminal amino acids 736-765 of Human Integrin beta 7 (NP_000880.1).

  • 阳性对照
    • WiDr cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab124223 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 87 kDa.

靶标

  • 功能Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.
  • 组织特异性Expressed in a variety of leukocyte lines.
  • 序列相似性Belongs to the integrin beta chain family.
    Contains 1 VWFA domain.
  • 结构域Domain I contains three cation-binding sites: the ligand-integrin-binding site (LIMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent to MIDAS site (ADMIDAS). In the absence of a ligand or in calcium-dependent binding, only ADMIDAS is occupied. In magnesium-dependent binding all three sites bind metal ions. LIMBS positively modify ligand binding whereas ADMIDAS negatively modify ligand binding.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Gut homing receptor beta subunit antibody
    • Integrin beta 7 subunit antibody
    • Integrin beta-7 antibody
    • Integrin beta-P antibody
    • Integrin, beta 7 antibody
    • ITB7 antibody
    • ITB7_HUMAN antibody
    • Itgb7 antibody
    • Ly69 antibody
    • M290 IEL antigen antibody
    see all

Anti-Integrin beta 7 antibody 图像

  • Anti-Integrin beta 7 antibody (ab124223) at 1/100 dilution + WiDr cell lysate at 35 µg

    Predicted band size : 87 kDa

Anti-Integrin beta 7 antibody (ab124223)参考文献

ab124223 has not yet been referenced specifically in any publications.

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