Anti-Integrin beta 4 binding protein抗体[EPR6512(B)] (ab124839)


  • 产品名称Anti-Integrin beta 4 binding protein抗体[EPR6512(B)]
    参阅全部 Integrin beta 4 binding protein 一抗
  • 描述
    兔单克隆抗体[EPR6512(B)] to Integrin beta 4 binding protein
  • 经测试应用适用于: WB, IHC-P, Flow Cytmore details
    不适用于: ICC or IP
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to residues in Human integrin beta 4 binding protein protein (P56537).

  • 阳性对照
    • HeLa, RAW 264.7, K562, 293T, and HepG2 cell lysates and Human colonic adenocarcinoma tissue.
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.



Our Abpromise guarantee covers the use of ab124839 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Predicted molecular weight: 27 kDa.
IHC-P 1/100 - 1/250. Antigen retrieval is recommended.
Flow Cyt 1/100 - 1/500. ab172730-Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.
  • 应用说明Is unsuitable for ICC or IP.
  • 靶标

    • 功能Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity.
    • 组织特异性Expressed at very high levels in colon carcinoma with lower levels in normal colon and ileum and lowest levels in kidney and muscle (at protein level).
    • 序列相似性Belongs to the eIF-6 family.
    • 翻译后修饰Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.
    • 细胞定位Cytoplasm. Nucleus > nucleolus. Shuttles between cytoplasm and nucleus/nucleolus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • b(2)gcn antibody
      • B(2)GCN homolog antibody
      • B4 integrin interactor antibody
      • Binding protein of beta-4 integrin antibody
      • CAB antibody
      • eIF-6 antibody
      • EIF3A antibody
      • EIF6 antibody
      • Eukaryotic translation initiation factor 3A antibody
      • Eukaryotic translation initiation factor 6 antibody
      • IF6_HUMAN antibody
      • ITGB4BP antibody
      • OK/SW-cl.27 antibody
      • p27 beta 4 integrin binding protein antibody
      • p27(BBP) antibody
      • p27BBP antibody
      • RP4-614O4.1 antibody
      see all

    Anti-Integrin beta 4 binding protein antibody [EPR6512(B)] 图像

    • All lanes : Anti-Integrin beta 4 binding protein antibody [EPR6512(B)] (ab124839) at 1/1000 dilution

      Lane 1 : HeLa cell lysate
      Lane 2 : RAW 264.7 cell lysate
      Lane 3 : K562 cell lysate
      Lane 4 : 293T cell lysate
      Lane 5 : HepG2 cell lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size : 27 kDa
    • ab124839, at 1/100 to 1/250, staining integrin beta 4 binding protein in Human colonic adenocarcinoma by immunohistochemistry [Paraffin Embedded Tissues (IHC-P)].

    Anti-Integrin beta 4 binding protein antibody [EPR6512(B)] (ab124839)参考文献

    ab124839 has not yet been referenced specifically in any publications.

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