生物素Anti-Integrin beta 4抗体[439-9B] (ab95584)
Key features and details
- Biotin Rat monoclonal [439-9B] to Integrin beta 4
- Suitable for: Flow Cyt
- Reacts with: Human
- Conjugation: Biotin
- Isotype: IgG2b
Related conjugates and formulations
概述
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产品名称
生物素Anti-Integrin beta 4抗体[439-9B]
参阅全部 Integrin beta 4 一抗 -
描述
生物素大鼠单克隆抗体[439-9B] to Integrin beta 4 -
宿主
Rat -
偶联物
Biotin -
经测试应用
适用于: Flow Cytmore details -
种属反应性
与反应: Human -
免疫原
Full length protein corresponding to Human Integrin beta 4. Native protein
Database link: P16144 -
阳性对照
- Flow Cyt: EDTA treated A549 cell line.
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常规说明
ab95584 has been reported to have no effect on adhesion of Human colon adenocarcinoma cells
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.20
Preservative: 0.09% Sodium azide
Constituent: PBS -
Concentration information loading...
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纯度
Protein G purified -
Primary antibody说明
ab95584 has been reported to have no effect on adhesion of Human colon adenocarcinoma cells -
克隆
单克隆 -
克隆编号
439-9B -
同种型
IgG2b -
研究领域
相关产品
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Alternative Versions
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab95584于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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Flow Cyt |
Use 0.25µg for 105-8 cells.
ab18542 - Rat monoclonal IgG2b, is suitable for use as an isotype control with this antibody. |
说明 |
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Flow Cyt
Use 0.25µg for 105-8 cells. ab18542 - Rat monoclonal IgG2b, is suitable for use as an isotype control with this antibody. |
靶标
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功能
Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. -
组织特异性
Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach. -
疾病相关
Defects in ITGB4 are a cause of epidermolysis bullosa letalis with pyloric atresia (EB-PA) [MIM:226730]; also known as junctional epidermolysis bullosa with pyloric atresia (PA-JEB) or aplasia cutis congenita with gastrointestinal atresia. EB-PA is an autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system. It is characterized by mucocutaneous fragility, aplasia cutis congenita, and gastrointestinal atresia, which most commonly affects the pylorus. Pyloric atresia is a primary manifestation rather than a scarring process secondary to epidermolysis bullosa.
Defects in ITGB4 are a cause of generalized atrophic benign epidermolysis bullosa (GABEB) [MIM:226650]. GABEB is a non-lethal, adult form of junctional epidermolysis bullosa characterized by life-long blistering of the skin, associated with hair and tooth abnormalities. -
序列相似性
Belongs to the integrin beta chain family.
Contains 1 Calx-beta domain.
Contains 4 fibronectin type-III domains.
Contains 1 PSI domain.
Contains 1 VWFA domain. -
结构域
The fibronectin type-III-like domains bind BPAG1 and plectin and probably also recruit BP230. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 3691 Human
- Omim: 147557 Human
- SwissProt: P16144 Human
- Unigene: 632226 Human
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别名
- CD 104 antibody
- CD104 antibody
- CD104 antigen antibody
see all
图片
数据表及文件
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Datasheet download
文献 (2)
ab95584 被引用在 2 文献中.
- Simon-Assmann P et al. Adhesive properties and integrin expression profiles of two colonic cancer populations differing by their spreading on laminin. J Cell Sci 107 ( Pt 3):577-87 (1994). PubMed: 8006072
- Falcioni R et al. Monoclonal antibody to human carcinoma-associated protein complex: quantitation in normal and tumor tissue. Cancer Res 48:816-21 (1988). PubMed: 2448027