Anti-Integrin beta 1d抗体[2B1] (ab8991)


  • 产品名称
    Anti-Integrin beta 1d抗体[2B1]
  • 描述
    小鼠单克隆抗体[2B1] to Integrin beta 1d
  • 特异性
    Recognizes specifically the cytoplasmic domain of integrin subunit beta 1D present in cardiac and skeletal muscle.
  • 经测试应用
    适用于: WB, IHC-Fr, ICCmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide: C-QENPIYKSPINNFKNPNYGRKAGL conjugated to KLH.

  • 表位
    Cytoplasmic domain, C-terminal. Isoform of the Integrin b1 subunit present in cardiac and skeletal muscle.
  • 常规说明

    The integrins, finally, form a large family of glycosylated transmembrane proteins that act as dimers of an alpha and a beta subunit in interconnecting the cytoskeleton and the extracellular matrix.


  • 形式
  • 存放说明
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液
    Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度
    Protein G purified
  • Primary antibody说明
    The integrins, finally, form a large family of glycosylated transmembrane proteins that act as dimers of an alpha and a beta subunit in interconnecting the cytoskeleton and the extracellular matrix.
  • 克隆
  • 克隆编号
  • 骨髓瘤
  • 同种型
  • 轻链类型
  • 研究领域


Our Abpromise guarantee covers the use of ab8991 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/1000.
IHC-Fr 1/25 - 1/200.
ICC Use at an assay dependent concentration.


  • 相关性
    Integrin beta 1, also known as CD29, is a 130 kDa transmembrane glycoprotein that forms noncovalent complexes with various Integrin alpha subunits (including alpha 1, alpha 2, alpha 3, alpha 4, alpha 5, and alpha 6, also known as CD49a, CD49b, CD49c, CD49d, CD49e, and CD49f, respectively) to form the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in the regulation of a variety of important biological functions, including embryonic development, wound repair, hemostasis, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and/or on adjacent cells. The clustering of integrins on a cell surface leads to the formation of focal contacts. Interactions between integrins and the extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression. The isoform beta-1D of Integrin 1, is expressed specifically in striated muscle (skeletal and cardiac muscle).
  • 细胞定位
    Cell Membrane
  • 数据库链接
  • 别名
    • CD29 antibody
    • FNRB antibody
    • Integrin beta 1 antibody
    • ITGB 1 antibody
    • ITGB1 antibody
    • MDF2 antibody
    • MSK12 antibody
    • VLAB antibody
    see all


  • Western blotting of beta1D integrin showing its muscle cell specific expression pattern.
  • Immunofluorescence staining of myocardium for beta1D integrin.


This product has been referenced in:
  • Barton ER  et al. Deletion of muscle GRP94 impairs both muscle and body growth by inhibiting local IGF production. FASEB J : (2012). ICC/IF ; Mouse . Read more (PubMed: 22649033) »
  • Barton ER Restoration of gamma-sarcoglycan localization and mechanical signal transduction are independent in murine skeletal muscle. J Biol Chem 285:17263-70 (2010). WB ; Mouse . Read more (PubMed: 20371873) »

See all 3 Publications for this product


Please forward the following publication to customer, there are many markers listed and we have antibodies against these. Customer might need to make decision based on their requirements.

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I would recommend to use an anti-integrin beta 1d such as or

Thank you for your enquiry. I am sorry it has taken a little time to obtain this protocol for you. Thank you for your patience. I hope this will be helpflu to you. Please note that this procedure would be a guideline only and may require some fur...

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We have just received the following information from the source of ab8991: "We would suggest to increase the protein concentration in the gel and to use more concentrated antibody for the blotting as this antibody is supplied as tissue culture supe...

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Thank you for your enquiry. For Western blotting, I would suggest starting at a dilution of 1:1000. For IHC, I would recommend titrating the antibody 1:20 to 1:200. For both applications, you will need to optimize based upon results. Please contact...

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We would expect this antibody to work on rat and mouse tissues, but cannot guarantee it. This epitope is conserved across species.