FITC荧光Anti-Integrin alpha V beta 3抗体[23C6] (ab93513)
Key features and details
- FITC Mouse monoclonal [23C6] to Integrin alpha V beta 3
- Suitable for: Flow Cyt
- Reacts with: Human
- Conjugation: FITC. Ex: 493nm, Em: 528nm
- Isotype: IgG1
Related conjugates and formulations
概述
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产品名称
FITC荧光Anti-Integrin alpha V beta 3抗体[23C6]
参阅全部 Integrin alpha V beta 3 一抗 -
描述
FITC荧光小鼠单克隆抗体[23C6] to Integrin alpha V beta 3 -
宿主
Mouse -
偶联物
FITC. Ex: 493nm, Em: 528nm -
经测试应用
适用于: Flow Cytmore details -
种属反应性
与反应: Human -
免疫原
Tissue, cells or virus corresponding to Integrin alpha V beta 3. Cell suspension containing osteoclasts from osteoclastomas.
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阳性对照
- M21 cells
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
pH: 7.20
Preservative: 0.09% Sodium azide
Constituents: 0.2% BSA, PBS, 0.1% Gelatin -
Concentration information loading...
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纯度
Protein G purified -
克隆
单克隆 -
克隆编号
23C6 -
同种型
IgG1 -
轻链类型
kappa -
研究领域
相关产品
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Alternative Versions
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab93513于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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Flow Cyt |
说明 |
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Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
靶标
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相关性
Function: The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 and ITGAV:ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C (PubMed:20615244). Integrin ITGAV:ITGB5 and ITGAV:ITGB3 act as receptors for coxsackievirus A9 and B1 (PubMed:9426447, PubMed:15194773, PubMed:7519807). Integrin ITGAV:ITGB3 acts as a receptor for herpes virus 8/HHV-8 (PubMed:18045938). Integrin ITGAV:ITGB6 acts as a receptor for herpes simplex 1/HHV-1 (PubMed:24367260). Integrin ITGAV:ITGB3 acts as a receptor for Human parechovirus 1 (PubMed:11160695). Integrin ITGAV:ITGB3 acts as a receptor for West nile virus (PubMed:23658209). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions (PubMed:10397733). Similarity: Belongs to the integrin alpha chain family. Contains 7 FG-GAP repeats. -
细胞定位
Cell Membrane. Cytoplasmic. Integrin complex. Focal adhesion. -
数据库链接
- Entrez Gene: 3685 Human
- Entrez Gene: 3690 Human
- Omim: 173470 Human
- Omim: 193210 Human
- SwissProt: P05106 Human
- SwissProt: P06756 Human
- Unigene: 436873 Human
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别名
- Antigen identified by monoclonal antibody L230 antibody
- CD 51 antibody
- CD 61 antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (4)
ab93513 被引用在 4 文献中.
- Weis EM et al. Ketone body oxidation increases cardiac endothelial cell proliferation. EMBO Mol Med 14:e14753 (2022). PubMed: 35179309
- Kuželová K et al. Group I p21-activated kinases in leukemia cell adhesion to fibronectin. Cell Adh Migr 15:18-36 (2021). PubMed: 33464167
- Kuželová K et al. Integrin expression and adhesivity to fibronectin in primary acute myeloid leukemia cells: Impact of NPM1 and FLT3 mutations. Eur J Haematol 105:578-587 (2020). PubMed: 32668024
- He X et al. Exploration of peptide T7 and its derivative as integrin avß3-targeted imaging agents. Onco Targets Ther 8:1483-91 (2015). Flow Cyt . PubMed: 26109872