Anti-Integrin alpha 6抗体[GoH3] (Biotin) (ab28080)

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概述

  • 产品名称
    Anti-Integrin alpha 6抗体[GoH3] (Biotin)
    参阅全部 Integrin alpha 6 一抗
  • 描述
    大鼠单克隆抗体[GoH3] to Integrin alpha 6 (Biotin)
  • 宿主
    Rat
  • 偶联物
    Biotin
  • 特异性
    ab28080 recognises CD49F (VLA-6 alpha chain)
  • 经测试应用
    适用于: Flow Cytmore details
  • 种属反应性
    与反应: Mouse, Dog, Human, Cynomolgus monkey
  • 免疫原

    Tissue/ cell preparation (Mouse) BALB/c mouse mammary tumour cells

性能

应用

Our Abpromise guarantee covers the use of ab28080 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt
  • 应用说明
    Flow Cyt: Use a working dilution of neat to 1/5. Use 10µl for 106 cells in 100ul.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • 靶标

    • 功能
      Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760).
    • 组织特异性
      Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney).
    • 疾病相关
      Epidermolysis bullosa letalis, with pyloric atresia
    • 序列相似性
      Belongs to the integrin alpha chain family.
      Contains 7 FG-GAP repeats.
    • 翻译后修饰
      Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation. Phosphorylation occurs on 'Ser-1103' of isoform alpha-6X1X2A. Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand.
      In invasive prostate cancer ITGA6 undergoes PLAU-mediated cleavage at residues Arg-634-635-Arg in a time-dependent manner enhancing cell invasion and migration in vitro.
      Palmitoylation by DHHC3 enhances stability and cell surface expression.
    • 细胞定位
      Cell membrane. Cell membrane.
    • Information by UniProt
    • 数据库链接
      • 别名
        • Alpha6p antibody
        • CD49 antigen-like family member F antibody
        • CD49f antibody
        • Integrin alpha6B antibody
        • Integrin, alpha 6 antibody
        • ITA6_HUMAN antibody
        • ITGA6 antibody
        • ITGA6B antibody
        • Processed integrin alpha-6 antibody
        • VLA 6 antibody
        • VLA-6 antibody
        see all

      图片

      • Flow Cytometry / FACS - Integrin alpha 6 antibody [NKI-GoH3] (ab28080)
        Flow Cytometry / FACS - Integrin alpha 6 antibody [NKI-GoH3] (ab28080)
        ab28080, at 10µl per 106 cells, staining human Integrin alpha 6 in peripheral blood lymphocytes by Flow Cytometry

      文献

      This product has been referenced in:
      • Lim E  et al. Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat Med 15:907-13 (2009). Read more (PubMed: 19648928) »
      • Yoshino N  et al. Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies. Exp Anim 49:97-110 (2000). Read more (PubMed: 10889948) »

      See all 3 Publications for this product

      发表研究结果有使用 ab28080？请让我们知道，以便我们可以引用本数据表中的参考文章。

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