Anti-Integrin alpha 6抗体[GoH3] (Biotin) (ab28080)

概述

• 产品名称
  Anti-Integrin alpha 6抗体[GoH3] (Biotin)
  参阅全部 Integrin alpha 6 一抗
• 描述
  大鼠单克隆抗体[GoH3] to Integrin alpha 6 (Biotin)
• 偶联物
  Biotin
• 特异性
  ab28080 recognises CD49F (VLA-6 alpha chain)
• 经测试应用
  适用于: Flow Cytmore details
• 种属反应性
  与反应: Mouse, Dog, Human, Cynomolgus monkey
  
• 免疫原

  Tissue/ cell preparation (Mouse) BALB/c mouse mammary tumour cells

性能

• 形式
  Liquid
• 存放说明
  Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• 存储溶液
  Preservative: 0.09% Sodium Azide
  Constituents: 1% BSA, PBS, pH 7.4
• Concentration information loading...
• 纯度
  Protein G purified
• 克隆
  单克隆
• 克隆编号
  GoH3
• 骨髓瘤
  Sp2/0
• 同种型
  IgG2a
• 研究领域
  • Signal Transduction
  • Cytoskeleton / ECM
  • Basal Lamina

  • Signal Transduction
  • Cytoskeleton / ECM
  • Cell Adhesion
  • Integrins
  • Alpha

  • Stem Cells
  • Embryonic Stem Cells
  • Surface Molecules

  • Stem Cells
  • Hematopoietic Progenitors
  • Myeloid
  • Monocytic Lineage

  • Developmental Biology
  • Embryogenesis
  • Embryonic stem cells
  • Intracellular

相关产品

• Compatible Secondaries
  • Goat Anti-Rat IgG H&L (Alexa Fluor® 488) (ab150157)
  • Goat Anti-Rat IgG H&L (HRP) (ab205720)

应用

靶标

• 功能
  Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760).
• 组织特异性
  Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney).
• 疾病相关
  Epidermolysis bullosa letalis, with pyloric atresia
• 序列相似性
  Belongs to the integrin alpha chain family.
  Contains 7 FG-GAP repeats.
• 翻译后修饰
  Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation. Phosphorylation occurs on 'Ser-1103' of isoform alpha-6X1X2A. Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand.
  In invasive prostate cancer ITGA6 undergoes PLAU-mediated cleavage at residues Arg-634-635-Arg in a time-dependent manner enhancing cell invasion and migration in vitro.
  Palmitoylation by DHHC3 enhances stability and cell surface expression.
• 细胞定位
  Cell membrane. Cell membrane.

• Target information above from: UniProt accession P23229 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 478800 Dog
  • Entrez Gene: 3655 Human
  • Entrez Gene: 16403 Mouse
  • Omim: 147556 Human
  • SwissProt: P23229 Human
  • SwissProt: Q61739 Mouse
  • Unigene: 133397 Human
• 别名
  • Alpha6p antibody
  • CD49 antigen-like family member F antibody
  • CD49f antibody

  • Integrin alpha6B antibody
  • Integrin, alpha 6 antibody
  • ITA6_HUMAN antibody
  • ITGA6 antibody
  • ITGA6B antibody
  • Processed integrin alpha-6 antibody
  • VLA 6 antibody
  • VLA-6 antibody

  see all

实验方案

• Flow cytometry protocols