Anti-Integrin alpha 4+beta 7抗体[DATK32 (DATK-32)] (Allophycocyanin) (ab93539)

概述

  • 产品名称Anti-Integrin alpha 4+beta 7抗体[DATK32 (DATK-32)] (Allophycocyanin)
    参阅全部 Integrin alpha 4+beta 7 一抗
  • 描述
    大鼠单克隆抗体[DATK32 (DATK-32)] to Integrin alpha 4+beta 7 (Allophycocyanin)
  • 偶联物Allophycocyanin. Ex: 645nm, Em: 660nm
  • 经测试应用适用于: Flow Cytmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Tissue/ cell preparation: AKR/Cum Mouse spontaneous T lymphoma cell line TK1.

  • 阳性对照
    • Mouse splenocytes and C57Bl/6 bone marrow cells
  • 常规说明


    Binding of the DATK32 monoclonal antibody has been shown to induce aggregation of the CD8+ T cell lymphoma TK1, and block Integrin alpha 4 beta 7 mediated cell adhesion.

性能

应用

Our Abpromise guarantee covers the use of ab93539 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use 0.125-0.5µg for 105-8 cells.

Use 0.125 - 0.5 µg for 105 - 108 cells in a 100 µl volume.

靶标

  • 相关性Integrin alpha 4 beta 7, also known as, the lymphocyte Peyer's patch adhesion molecule (LPAM1) is a member of the integrin family of cell surface receptors. It is expressed primarily on mucosal lymphocytes, but is also present on NK cells and eosinophils. The alpha 4 beta 7 heterodimer mediates the binding of lymphocytes to its ligand, mucosal vascular addressin (MAdCAM1) on the high endothelial venules, thereby directing the homing of lymphocytes into Peyer's patches and intestinal lamina propria.
  • 细胞定位Membrane; Single pass type I membrane protein.
  • 数据库链接
  • 别名
    • Antigen CD49D antibody
    • CD49d antibody
    • IA4 antibody
    • Integrin alpha 4 subunit antibody
    • Integrin alpha IV antibody
    • Integrin beta 7 antibody
    • Integrin beta 7 subunit antibody
    • ITGA4 antibody
    • ITGB7 antibody
    • LPAM1 antibody
    see all

Anti-Integrin alpha 4+beta 7 antibody [DATK32 (DATK-32)] (Allophycocyanin) 图像

  • Staining of C57Bl/6 bone marrow cells with FITC anti-Mouse/Human B220 (RA3-6B2) and 0.125 µg of APC Rat IgG2a Isotype Control (left), or 0.125 µg of ab93539 (right). Total viable cells were used for analysis.

Anti-Integrin alpha 4+beta 7 antibody [DATK32 (DATK-32)] (Allophycocyanin) (ab93539)参考文献

This product has been referenced in:
  • Andrew DP  et al. Distinct but overlapping epitopes are involved in alpha 4 beta 7-mediated adhesion to vascular cell adhesion molecule-1, mucosal addressin-1, fibronectin, and lymphocyte aggregation. J Immunol 153:3847-61 (1994). Flow Cyt . Read more (PubMed: 7523506) »
  • Hamann A  et al. Role of alpha 4-integrins in lymphocyte homing to mucosal tissues in vivo. J Immunol 152:3282-93 (1994). Flow Cyt . Read more (PubMed: 7511642) »

See all 3 Publications for this product

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