Anti-Integrin alpha 4+beta 7抗体[DATK32] (Biotin) (ab25217)

概述

  • 产品名称Anti-Integrin alpha 4+beta 7抗体[DATK32] (Biotin)
    参阅全部 Integrin alpha 4+beta 7 一抗
  • 描述
    大鼠单克隆抗体[DATK32] to Integrin alpha 4+beta 7 (Biotin)
  • 偶联物Biotin
  • 经测试应用适用于: Flow Cyt, IHC-Fr, Blockingmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    AKR/Cum Mouse spontaneous T lymphoma cell line TK1.

  • 表位ab25217 recognizes a conformational epitope on the heterodimer.
  • 常规说明


    ab25217 could be useful for induction of homotypic cellular aggregation.

性能

应用

Our Abpromise guarantee covers the use of ab25217 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use 1µg for 106 cells. ab18445-Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
IHC-Fr Use at an assay dependent concentration.
Blocking Use at an assay dependent concentration.

靶标

  • 相关性Integrin alpha 4 beta 7, also known as, the lymphocyte Peyer's patch adhesion molecule (LPAM1) is a member of the integrin family of cell surface receptors. It is expressed primarily on mucosal lymphocytes, but is also present on NK cells and eosinophils. The alpha 4 beta 7 heterodimer mediates the binding of lymphocytes to its ligand, mucosal vascular addressin (MAdCAM1) on the high endothelial venules, thereby directing the homing of lymphocytes into Peyer's patches and intestinal lamina propria.
  • 细胞定位Membrane; Single pass type I membrane protein.
  • 数据库链接
  • 别名
    • Antigen CD49D antibody
    • CD49d antibody
    • IA4 antibody
    • Integrin alpha 4 subunit antibody
    • Integrin alpha IV antibody
    • Integrin beta 7 antibody
    • Integrin beta 7 subunit antibody
    • ITGA4 antibody
    • ITGB7 antibody
    • LPAM1 antibody
    see all

Anti-Integrin alpha 4+beta 7 antibody [DATK32] (Biotin) (ab25217)参考文献

This product has been referenced in:
  • Andrew DP  et al. Distinct but overlapping epitopes are involved in alpha 4 beta 7-mediated adhesion to vascular cell adhesion molecule-1, mucosal addressin-1, fibronectin, and lymphocyte aggregation. J Immunol 153:3847-61 (1994). Read more (PubMed: 7523506) »
  • Hamann A  et al. Role of alpha 4-integrins in lymphocyte homing to mucosal tissues in vivo. J Immunol 152:3282-93 (1994). Read more (PubMed: 7511642) »

See all 2 Publications for this product

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