Anti-Integrin alpha 4抗体[PS/2] (Phycoerythrin) (ab24854)


  • 产品名称Anti-Integrin alpha 4抗体[PS/2] (Phycoerythrin)
    参阅全部 Integrin alpha 4 一抗
  • 描述
    大鼠单克隆抗体[PS/2] to Integrin alpha 4 (Phycoerythrin)
  • 偶联物Phycoerythrin. Ex: 488nm, Em: 575nm
  • 特异性This antibody is specific to CD49d, the alpha4 chain of the VLA4 integrin heterodimer.
  • 经测试应用适用于: Functional Studies, IP, Flow Cytmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    The details of the immunogen for this antibody are not available.



Our Abpromise guarantee covers the use of ab24854 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Functional Studies Use at an assay dependent concentration.

Studies of cell-cell interaction and tumor cell metastasis and adhesion, Inhibition of lymphopoiesis in Whitlock-Witte long-term bone marrow cultures and Retardation of myelopoiesis in Dexter-type cultures.

IP Use at an assay dependent concentration.
Flow Cyt Use 0.2µg for 106 cells.

ab136585 - Rat monoclonal IgG2b, is suitable for use as an isotype control with this antibody.


  • 功能Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.
  • 序列相似性Belongs to the integrin alpha chain family.
    Contains 7 FG-GAP repeats.
  • 结构域The SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan and cell adhesion.
  • 翻译后修饰Phosphorylation on Ser-1027 inhibits PXN binding.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 269C wild type antibody
    • Antigen CD49D, alpha 4 subunit of VLA 4 receptor antibody
    • CD49 antigen like family member D antibody
    • CD49 antigen-like family member D antibody
    • CD49d antibody
    • IA4 antibody
    • Integrin alpha 4 antibody
    • Integrin alpha 4 subunit antibody
    • Integrin alpha IV antibody
    • Integrin alpha-4 antibody
    • Integrin alpha-IV antibody
    • Integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA 4 receptor) antibody
    • ITA4_HUMAN antibody
    • ITGA4 antibody
    • MGC90518 antibody
    • OTTHUMP00000205320 antibody
    • Very late activation protein 4 receptor, alpha 4 subunit antibody
    • VLA 4 subunit alpha antibody
    • VLA-4 subunit alpha antibody
    • VLA4 antibody
    see all

Anti-Integrin alpha 4 antibody [PS/2] (Phycoerythrin) 图像

  • Flow cytometry analysis staining Integrin alpha 4 in mouse splenocytes using ab24854 at a dilution of 0.1 µg/106 cells.

Anti-Integrin alpha 4 antibody [PS/2] (Phycoerythrin) (ab24854)参考文献

ab24854 has not yet been referenced specifically in any publications.

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