Anti-Integrin alpha 4抗体[AP-MAB0865] (ab80944)

概述

  • 产品名称
    Anti-Integrin alpha 4抗体[AP-MAB0865]
    参阅全部 Integrin alpha 4 一抗
  • 描述
    大鼠单克隆抗体[AP-MAB0865] to Integrin alpha 4
  • 宿主
    Rat
  • 经测试应用
    适用于: IP, Flow Cyt, Blocking, IHC-Frmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Tissue, cells or virus corresponding to Mouse Integrin alpha 4.

性能

应用

Our Abpromise guarantee covers the use of ab80944 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP
Flow Cyt
Blocking
IHC-Fr
  • 应用说明
    BL of cell cell adhesion: Use at an assay dependent dilution.
    Flow Cyt: Use at an assay dependent dilution.
    IHC-P: Use at an assay dependent dilution.
    IP: Use at an assay dependent dilution.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能
      Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.
    • 序列相似性
      Belongs to the integrin alpha chain family.
      Contains 7 FG-GAP repeats.
    • 结构域
      The SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan and cell adhesion.
    • 翻译后修饰
      Phosphorylation on Ser-1027 inhibits PXN binding.
    • 细胞定位
      Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 269C wild type antibody
      • Antigen CD49D, alpha 4 subunit of VLA 4 receptor antibody
      • CD49 antigen like family member D antibody
      • CD49 antigen-like family member D antibody
      • CD49d antibody
      • IA4 antibody
      • Integrin alpha 4 antibody
      • Integrin alpha 4 subunit antibody
      • Integrin alpha IV antibody
      • Integrin alpha-4 antibody
      • Integrin alpha-IV antibody
      • Integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA 4 receptor) antibody
      • ITA4_HUMAN antibody
      • ITGA4 antibody
      • MGC90518 antibody
      • OTTHUMP00000205320 antibody
      • Very late activation protein 4 receptor, alpha 4 subunit antibody
      • VLA 4 subunit alpha antibody
      • VLA-4 subunit alpha antibody
      • VLA4 antibody
      see all

    文献

    ab80944 has not yet been referenced specifically in any publications.

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