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功能
Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.
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组织特异性
Isoform alpha-3A is widely expressed. Isoform alpha-3B is expressed in brain and heart. In brain, both isoforms are exclusively expressed on vascular smooth muscle cells, whereas in heart isoform alpha-3A is strongly expressed on vascular smooth muscle cells, isoform alpha-3B is detected only on endothelial vein cells.
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序列相似性
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
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翻译后修饰
Isoform alpha-3A, but not isoform alpha-3B, is phosphorylated on serine residues. Phosphorylation increases after phorbol 12-myristate 13-acetate stimulation. Isoform alpha-3A is phosphorylated on Tyr-1051.
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细胞定位
Membrane.
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Information by UniProt
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数据库链接
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别名
- AA407068 antibody
- Antigen identified by monoclonal antibody J143 antibody
- CD49 antigen like family member C antibody
- CD49 antigen-like family member C antibody
- CD49c antibody
- CD49c antigen antibody
- FLJ34631 antibody
- FLJ34704 antibody
- FRP 2 antibody
- FRP-2 antibody
- FRP2 antibody
- Galactoprotein B3 antibody
- GAP B3 antibody
- GAPB3 antibody
- Integrin alpha 3 antibody
- Integrin alpha-3 light chain antibody
- Integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) antibody
- ITA3_HUMAN antibody
- ITGA 3 antibody
- Itga3 antibody
- MSK18 antibody
- VCA 2 antibody
- VCA2 antibody
- Very late activation protein 3 receptor alpha 3 subunit antibody
- VL3A antibody
- VLA 3 alpha chain antibody
- VLA 3 subunit alpha antibody
- VLA-3 subunit alpha antibody
- VLA3a antibody
see all