Anti-Integrin alpha 3抗体[F35 177-1] (ab20140)
- 数据表
- 具体的参考文献 (1)
- 实验方案
概述
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产品名称Anti-Integrin alpha 3抗体[F35 177-1]
参阅全部 Integrin alpha 3 一抗 -
描述小鼠单克隆抗体[F35 177-1] to Integrin alpha 3
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宿主Mouse
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经测试应用适用于: IHC-Fr, IHC-FoFrmore details
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种属反应性与反应: Human
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免疫原
Cell preparation: MTSV1-7 HYE - human breast epithelial cells
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常规说明Fusion Partner: NS2
性能
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形式Liquid
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存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
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存储溶液Preservative: None
Constituents: PBS -
Concentration information loading... -
克隆单克隆
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克隆编号F35 177-1
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同种型IgG1
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轻链类型unknown
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研究领域
相关产品
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Compatible Secondaries
应用
Our Abpromise guarantee covers the use of ab20140 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-Fr | Use at an assay dependent concentration. Fix with acetone. | |
| IHC-FoFr | Use at an assay dependent concentration. |
靶标
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功能Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.
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组织特异性Isoform alpha-3A is widely expressed. Isoform alpha-3B is expressed in brain and heart. In brain, both isoforms are exclusively expressed on vascular smooth muscle cells, whereas in heart isoform alpha-3A is strongly expressed on vascular smooth muscle cells, isoform alpha-3B is detected only on endothelial vein cells.
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序列相似性Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats. -
翻译后修饰Isoform alpha-3A, but not isoform alpha-3B, is phosphorylated on serine residues. Phosphorylation increases after phorbol 12-myristate 13-acetate stimulation. Isoform alpha-3A is phosphorylated on Tyr-1051.
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细胞定位Membrane.
- Information by UniProt
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数据库链接
- Entrez Gene: 3675 Human
- Omim: 605025 Human
- SwissProt: P26006 Human
- Unigene: 265829 Human
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别名
- AA407068 antibody
- Antigen identified by monoclonal antibody J143 antibody
- CD49 antigen like family member C antibody
see all
图片
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![Immunohistochemistry (Frozen sections) - Anti-Integrin alpha 3 antibody [F35 177-1] (ab20140)](http://www.abcam.cn/ps/products/20/ab20140/Images/ab20140-271335-ab20140IHCFr.jpg)
Immunohistochemistry (Frozen sections) - Anti-Integrin alpha 3 antibody [F35 177-1] (ab20140)Immunohistochemistry (Frozen sections) analysis of human skin tissue sections labeling Integrin alpha 3 with ab20140 at 1/1000 dilution. An undiluted goat anti-mouse polyclonal alkaline phosphatase conjugate was used as the secondary antibody.
文献
This product has been referenced in:
- Lustosa SA et al. Expression profiling using a cDNA array and immunohistochemistry for the extracellular matrix genes FN-1, ITGA-3, ITGB-5, MMP-2, and MMP-9 in colorectal carcinoma progression and dissemination. ScientificWorldJournal 2014:102541 (2014). IHC ; Human . Read more (PubMed: 24737953) »
客户评价及客户问答
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"