Anti-Integrin alpha 2抗体[DX5] (Phycoerythrin) (ab25493)


  • 产品名称
    Anti-Integrin alpha 2抗体[DX5] (Phycoerythrin)
    参阅全部 Integrin alpha 2 一抗
  • 描述
    大鼠单克隆抗体[DX5] to Integrin alpha 2 (Phycoerythrin)
  • 偶联物
    Phycoerythrin. Ex: 488nm, Em: 575nm
  • 特异性
    ab25493 recognises integrin alpha 2.
  • 经测试应用
    适用于: Flow Cytmore details
    不适用于: IHC-Fr or IHC-P
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Tissue/ cell preparation: RIL 2 propagated NK1.1 positive cells from C57BL/6 mice.

  • 常规说明

    NK cells cultured in the presence of IL2 progressively lose reactivity with DX5 as a consequence of cellular proliferation. Therefore, DX5 can be used to define functionally distinct subsets of murine NK cells. DX5 has not been demonstrated to have activating or blocking activity.



Our Abpromise guarantee covers the use of ab25493 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use 0.2µg for 106 cells.

ab25493 can be used to define functionally distinct subsets of murine NK cells.

  • 应用说明
    Is unsuitable for IHC-Fr or IHC-P.
  • 靶标

    • 功能
      Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
    • 序列相似性
      Belongs to the integrin alpha chain family.
      Contains 7 FG-GAP repeats.
      Contains 1 VWFA domain.
    • 结构域
      The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
    • 细胞定位
    • Information by UniProt
    • 数据库链接
    • 别名
      • BR antibody
      • CD 49b antibody
      • CD49 antigen like family member B antibody
      • CD49 antigen-like family member B antibody
      • CD49b antibody
      • CD49b antigen antibody
      • Collagen receptor antibody
      • DX5 antibody
      • Glycoprotein Ia deficiency included antibody
      • GP Ia antibody
      • GP Ia deficiency, included antibody
      • GPIa antibody
      • HPA 5 included antibody
      • HPA5 included antibody
      • Human platelet alloantigen system 5 antibody
      • Integrin alpha 2 antibody
      • Integrin alpha II antibody
      • Integrin alpha-2 antibody
      • Integrin, alpha 2 (CD49B alpha 2 subunit of VLA 2 receptor) antibody
      • ITA2_HUMAN antibody
      • ITGA2 antibody
      • Platelet alloantigen Br(a), included antibody
      • Platelet antigen Br antibody
      • Platelet glycoprotein GPIa antibody
      • Platelet glycoprotein Ia antibody
      • Platelet glycoprotein Ia/IIa antibody
      • Platelet membrane glycoprotein Ia antibody
      • Platelet receptor for collagen, deficiency of, included antibody
      • Very late activation protein 2 receptor alpha 2 subunit antibody
      • VLA 2 alpha chain antibody
      • VLA 2 antibody
      • VLA 2 subunit alpha antibody
      • VLA-2 subunit alpha antibody
      • VLA2 antibody
      • VLA2 receptor alpha 2 subunit antibody
      • VLAA2 antibody
      see all


    • Flow Cytometry analysis of C57BL/6 mouse splenocytes stained with Anti-Integrin alpha 2 antibody [DX5] (Phycoerythrin) (ab25493) and mouse anti-mouse NK1.1-FITC.


    This product has been referenced in:
    • Arase H  et al. Cutting edge: the mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (alpha 2 integrin, very late antigen-2). J Immunol 167:1141-4 (2001). Read more (PubMed: 11466327) »

    See 1 Publication for this product


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