重组
RabMAb

Anti-Insulin Receptor R抗体[EP327Y] (ab40782)

概述

  • 产品名称
    Anti-Insulin Receptor R抗体[EP327Y]
    参阅全部 Insulin Receptor R 一抗
  • 描述
    兔单克隆抗体[EP327Y] to Insulin Receptor R
  • 特异性
    ab40782 recognises insulin receptor related receptor (IRR).
  • 经测试应用
    适用于: WB, IHC-Pmore details
    不适用于: Flow Cyt or IP
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to residues near the N-terminus of human IRR alpha subunit.

  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

性能

应用

Our Abpromise guarantee covers the use of ab40782 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/2000. Predicted molecular weight: 80, 144 kDa.
IHC-P 1/50 - 1/100.
  • 应用说明
    Is unsuitable for Flow Cyt or IP.
  • 靶标

    • 功能
      This receptor probably binds an insulin related protein and has a tyrosine-protein kinase activity. It phosphorylates the insulin receptor substrates IRS-1 and IRS-2.
    • 序列相似性
      Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
      Contains 3 fibronectin type-III domains.
      Contains 1 protein kinase domain.
    • 细胞定位
      Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • INSRR antibody
      • INSRR_HUMAN antibody
      • Insulin receptor related receptor precursor antibody
      • Insulin receptor-related protein alpha chain antibody
      • Insulin receptor-related protein beta chain antibody
      • insulin receptor-related receptor antibody
      • IR R antibody
      • IR related receptor antibody
      • IR-related receptor antibody
      • IRR antibody
      • Sir r antibody
      • Sirr antibody
      see all

    图片

    • All lanes : Anti-Insulin Receptor R antibody [EP327Y] (ab40782) at 1/2000 dilution

      Lane 1 : PC12
      Lane 2 : MCF7
      Lane 3 : Hela
      Lane 4 : SHSY5Y

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 80, 144 kDa
      Observed band size : 80 kDa (why is the actual band size different from the predicted?)
      Additional bands at : 130 kDa,37 kDa. We are unsure as to the identity of these extra bands.
    • Immunohistochemical analysis of paraffin-embedded human kidney tissue using ab40782.

    文献

    This product has been referenced in:
    • Wang L  et al. Exosomes derived from pancreatic cancer cells induce insulin resistance in C2C12 myotube cells through the PI3K/Akt/FoxO1 pathway. Sci Rep 7:5384 (2017). Read more (PubMed: 28710412) »
    • Li Y  et al. LRP4 mutations alter Wnt/beta-catenin signaling and cause limb and kidney malformations in Cenani-Lenz syndrome. Am J Hum Genet 86:696-706 (2010). WB ; Human . Read more (PubMed: 20381006) »

    See all 2 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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