Anti-Insulin degrading enzyme / IDE抗体(ab62829)

概述

  • 产品名称Anti-Insulin degrading enzyme / IDE抗体
    参阅全部 Insulin degrading enzyme / IDE 一抗
  • 描述
    山羊多克隆抗体to Insulin degrading enzyme / IDE
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Mouse, Rat
    预测可用于: Cow, Human, Zebrafish
  • 免疫原

    Synthetic peptide:

    C-QQYNYDRDNIE

    , corresponding to internal sequence amino acids 914-924 of Mouse Insulin degrading enzyme/ IDE

  • 阳性对照
    • Mouse Brain lysate

性能

应用

Our Abpromise guarantee covers the use of ab62829 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 110 kDa (predicted molecular weight: 118 kDa).
ELISA 1/16000.

靶标

  • 功能Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.
  • 序列相似性Belongs to the peptidase M16 family.
  • 翻译后修饰The N-terminus is blocked.
  • 细胞定位Cytoplasm. Cell surface. Present at the cell surface of neuron cells. The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Abeta-degrading protease antibody
    • FLJ35968 antibody
    • Ide antibody
    • IDE_HUMAN antibody
    • Insulin protease antibody
    • Insulin-degrading enzyme antibody
    • Insulinase antibody
    • Insulysin antibody
    • OTTHUMP00000020097 antibody
    see all

Anti-Insulin degrading enzyme / IDE antibody 图像

  • Anti-Insulin degrading enzyme / IDE antibody (ab62829) at 1 µg/ml + Mouse brain lysate at 35 µg

    Predicted band size : 118 kDa
    Observed band size : 110 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 30 kDa. We are unsure as to the identity of these extra bands.

Anti-Insulin degrading enzyme / IDE antibody (ab62829)参考文献

ab62829 has not yet been referenced specifically in any publications.

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