Anti-Insulin抗体[EPR3075] (ab108326)

概述

• 产品名称
  Anti-Insulin抗体[EPR3075]
  参阅全部 Insulin 一抗
• 描述
  兔单克隆抗体[EPR3075] to Insulin
• 经测试应用
  适用于: WB, IHC-Pmore details
  不适用于: Flow Cyt,ICC or IP
• 种属反应性
  与反应: Human
  
• 免疫原

  Synthetic peptide within Human Insulin aa 50 to the C-terminus. The exact sequence is proprietary.

• 阳性对照
  • Human fetal pancreas lysate; Human pancreas tissue.
• 常规说明

  This product is a recombinant rabbit monoclonal antibody.

  Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

  Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab^® patents

性能

• 形式
  Liquid
• 存放说明
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• 存储溶液
  PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• 纯度
  Tissue culture supernatant
• 克隆
  单克隆
• 克隆编号
  EPR3075
• 同种型
  IgG
• 研究领域
  • Signal Transduction
  • Growth Factors/Hormones
  • Insulin / Insulin-like

  • Neuroscience
  • Neurology process
  • Metabolism

  • Cardiovascular
  • Atherosclerosis
  • Diabetes associated

  • Metabolism
  • Types of disease
  • Diabetes

  • Metabolism
  • Types of disease
  • Obesity

  • Metabolism
  • Types of disease
  • Cancer

  • Metabolism
  • Types of disease
  • Heart disease

应用

靶标

• 功能
  Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
• 疾病相关
  Defects in INS are the cause of familial hyperproinsulinemia (FHPRI) [MIM:176730].
  Defects in INS are a cause of diabetes mellitus insulin-dependent type 2 (IDDM2) [MIM:125852]. IDDM2 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
  Defects in INS are a cause of diabetes mellitus permanent neonatal (PNDM) [MIM:606176]. PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.
  Defects in INS are a cause of maturity-onset diabetes of the young type 10 (MODY10) [MIM:613370]. MODY10 is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
• 序列相似性
  Belongs to the insulin family.
• 细胞定位
  Secreted.

• Target information above from: UniProt accession P01308 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 3630 Human
  • Omim: 176730 Human
  • SwissProt: P01308 Human
  • Unigene: 272259 Human
• 别名
  • IDDM antibody
  • IDDM1 antibody
  • IDDM2 antibody

  • ILPR antibody
  • ins antibody
  • INS_HUMAN antibody
  • Insulin A chain antibody
  • Insulin B chain antibody
  • IRDN antibody
  • MODY10 antibody
  • Preproinsulin antibody
  • Proinsulin antibody
  • Proinsulin precursor antibody

  see all

实验方案

• Western blot protocols
• Immunohistochemistry protocols