Anti-Insulin抗体[EPR3075] (ab108326)


  • 产品名称Anti-Insulin抗体[EPR3075]
    参阅全部 Insulin 一抗
  • 描述
    兔单克隆抗体[EPR3075] to Insulin
  • 经测试应用适用于: WB, IHC-Pmore details
    不适用于: Flow Cyt,ICC or IP
  • 种属反应性
    与反应: Human
  • 免疫原

    A synthetic peptide corresponding to residues in Human C Peptide.

  • 阳性对照
    • Human fetal pancreas lysate; Human pancreas tissue.
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.




Our Abpromise guarantee covers the use of ab108326 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Predicted molecular weight: 12 kDa.
IHC-P 1/100 - 1/250. Perform antigen retrieval.
  • 应用说明Is unsuitable for Flow Cyt,ICC or IP.
  • 靶标

    • 功能Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
    • 疾病相关Defects in INS are the cause of familial hyperproinsulinemia (FHPRI) [MIM:176730].
      Defects in INS are a cause of diabetes mellitus insulin-dependent type 2 (IDDM2) [MIM:125852]. IDDM2 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
      Defects in INS are a cause of diabetes mellitus permanent neonatal (PNDM) [MIM:606176]. PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.
      Defects in INS are a cause of maturity-onset diabetes of the young type 10 (MODY10) [MIM:613370]. MODY10 is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
    • 序列相似性Belongs to the insulin family.
    • 细胞定位Secreted.
    • Information by UniProt
    • 数据库链接
    • 别名
      • IDDM antibody
      • IDDM1 antibody
      • IDDM2 antibody
      • ILPR antibody
      • ins antibody
      • INS_HUMAN antibody
      • Insulin A chain antibody
      • Insulin B chain antibody
      • IRDN antibody
      • MODY10 antibody
      • Preproinsulin antibody
      • Proinsulin antibody
      • Proinsulin precursor antibody
      see all

    Anti-Insulin antibody [EPR3075] 图像

    • Anti-Insulin antibody [EPR3075] (ab108326) at 1/1000 dilution + Human fetal pancreas lysate at 10 µg

      Predicted band size : 12 kDa
    • ab108326 at 1/100 dilution staining C peptide in Human pancreas by Immunohistochemistry, Paraffin-embedded tissue.

    Anti-Insulin antibody [EPR3075] (ab108326)参考文献

    ab108326 has not yet been referenced specifically in any publications.

    Product Wall

    Gracias por escribirnos.

    Si lo que quiere la clienta es un anticuerpo contra C peptide para ICC que reaccione en humano, existen varias opciones.

    Si lo que requiere además es que no reaccione con rata ni ratón me temo ...

    Read More

    Thank you for your inquiry.

    For ab8297, we have never tested this antibody for cross-reactivity with mouse or rat. Therefore, we would not be able to guarantee it for non-cross-reactivity with mouse and rat.

    For ab108326, this antib...

    Read More