Anti-Insulin抗体[D4B8] (ab8303)


  • 产品名称Anti-Insulin抗体[D4B8]
    参阅全部 Insulin 一抗
  • 描述
    小鼠单克隆抗体[D4B8] to Insulin
  • 特异性Human insulin
  • 经测试应用适用于: IHC-Frmore details
  • 种属反应性
    与反应: Cow, Human, Pig
  • 免疫原

    Full length native protein (purified) (Human).

  • 常规说明Kass for clone D4B8 is 1.5 x 108M-1



Our Abpromise guarantee covers the use of ab8303 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
  • 应用说明This antibody recognises a different epitope ab8302 (7F8)
    Immunohistochemistry on frozen sections.
  • 靶标

    • 功能Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
    • 疾病相关Defects in INS are the cause of familial hyperproinsulinemia (FHPRI) [MIM:176730].
      Defects in INS are a cause of diabetes mellitus insulin-dependent type 2 (IDDM2) [MIM:125852]. IDDM2 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
      Defects in INS are a cause of diabetes mellitus permanent neonatal (PNDM) [MIM:606176]. PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.
      Defects in INS are a cause of maturity-onset diabetes of the young type 10 (MODY10) [MIM:613370]. MODY10 is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
    • 序列相似性Belongs to the insulin family.
    • 细胞定位Secreted.
    • Information by UniProt
    • 数据库链接
    • 别名
      • IDDM antibody
      • IDDM1 antibody
      • IDDM2 antibody
      • ILPR antibody
      • ins antibody
      • INS_HUMAN antibody
      • Insulin A chain antibody
      • Insulin B chain antibody
      • IRDN antibody
      • MODY10 antibody
      • Preproinsulin antibody
      • Proinsulin antibody
      • Proinsulin precursor antibody
      see all

    Anti-Insulin antibody [D4B8] (ab8303)参考文献

    ab8303 has not yet been referenced specifically in any publications.

    Product Wall

    Here is the rest of the information for your customer: Ab1968 - this clone (C7C9) reacts with the c-terminal pentapeptide of the insulin beta-chain. There is unfortunately no epitope information for ab1966 (clone 7F5). If you have any more questions ju...

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    Thanks for your patience with this one. Here is the epitope information - Ab7760: The epitope specificity was not performed. It reacts with high affinity with the whole insulin molecule (native, under the conditions of RIA) but with much lower affi...

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    Unfortunately the antibodies have only been tested with native insulin.

    In cases where the epitope of a given monoclonal antibody is known, this information is recorded on the datasheet. None of our monoclonal antibodies to insulin are know to recognise this sequence.