概述

  • 产品名称
  • 描述
    兔多克隆抗体to INSL3
  • 经测试应用
    适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human, Rhesus monkey
    预测可用于: Rat
  • 免疫原

    Synthetic peptide, corresponding to C terminal amino acids 115-131 of Human INSL3, differing from the related rat and mouse sequence by three amino acids.

  • 阳性对照
    • Human testicle sections

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液
    Preservative: 0.02% Sodium Azide, 0.01% Thimerosal (merthiolate)
    Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Dibasic monohydrogen sodium phosphate
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab65981 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 14 kDa.
IHC-P Use a concentration of 1 - 2 µg/ml.

靶标

  • 功能
    Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.
  • 组织特异性
    Expressed in prenatal and postnatal Leydig cells. Found as well in the corpus luteum, trophoblast, fetal membranes and breast.
  • 疾病相关
    Defects in INSL3 seems to be a cause of cryptorchidism (CRYPTO) [MIM:219050]; also known as impaired testicular descent. It is one of the most frequent congenital abnormalities in humans, involving 2-5% of male births. Cryptorchidism is associated with increased risk of infertility and testicular cancer. The frequency of INSL3 gene mutations as a cause of cryptorchidism is low.
  • 序列相似性
    Belongs to the insulin family.
  • 细胞定位
    Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • INSL 3 antibody
    • INSL3 antibody
    • INSL3_HUMAN antibody
    • Insulin like 3 antibody
    • insulin like peptide, Leydig cell-specific antibody
    • insulin-like 3 (Leydig cell) antibody
    • Insulin-like 3 A chain antibody
    • Ley IL antibody
    • Ley-I-L antibody
    • leydig insulin -like hormone antibody
    • Leydig insulin like peptide antibody
    • Leydig insulin-like peptide antibody
    • prepro-INSL3 antibody
    • Relaxin like factor antibody
    • Relaxin-like factor antibody
    • relaxin-like factor b antibody
    • RLF antibody
    • RLNL antibody
    see all

图片

  • Immunohistochemical analysis of paraffin-embedded human testicle staining INSL3 in cytoplasm using ab65981 at 2µg/ml. DAB chromogenic reaction.

文献

This product has been referenced in:
  • Fouquet B  et al. Ovarian-like differentiation in eutopic and ectopic endometrioses with aberrant FSH receptor, INSL3 and GATA4/6 expression. BBA Clin 6:143-152 (2016). IHC-P ; Human . Read more (PubMed: 27882303) »
  • Hanna CB  et al. Expression of insulin-like 3 (INSL3) and differential splicing of its receptor in the ovary of rhesus macaques. Reprod Biol Endocrinol 8:150 (2010). WB, IHC-P ; Rhesus monkey . Read more (PubMed: 21138583) »

See all 2 Publications for this product

客户评价及客户问答

There are currently no Customer reviews or Questions for ab65981.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

注册