概述

  • 产品名称Anti-ING4抗体
    参阅全部 ING4 一抗
  • 描述
    兔多克隆抗体to ING4
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Recombinant fragment, corresponding to internal sequence amino acids 33-183 of Human ING4, isoform 3 (BC007781).

  • 阳性对照
    • Human fetal liver, fetal kidney and Mouse kidney lysates; Human fetal brain tissue.

性能

应用

Our Abpromise guarantee covers the use of ab113425 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 25 kDa (predicted molecular weight: 26 kDa).
IHC-P 1/100 - 1/500.

靶标

  • 功能Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1).
  • 序列相似性Belongs to the ING family.
    Contains 1 PHD-type zinc finger.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Brain my036 protein antibody
    • Candidate tumor suppressor p33 ING 1 homolog antibody
    • Candidate tumor suppressor p33 ING1 homolog antibody
    • D6Wsu147e antibody
    • D6Xrf92 antibody
    • ING 1 like protein antibody
    • ING 4 antibody
    • ING1 like protein antibody
    • ING4 antibody
    • ING4_HUMAN antibody
    • Inhibitor of growth family member 4 antibody
    • Inhibitor of growth family member 4 long isoform antibody
    • Inhibitor of growth protein 4 antibody
    • MGC12557 antibody
    • my036 antibody
    • p29 ING 4 antibody
    • p29 ING4 antibody
    • p29ING4 antibody
    see all

Anti-ING4 antibody 图像

  • All lanes : Anti-ING4 antibody (ab113425) at 1/500 dilution

    Lane 1 : Human fetal liver lysate
    Lane 2 : Human fetal kidney lysate
    Lane 3 : Mouse kidney lysate


    Predicted band size : 26 kDa
  • ab113425 at 1/100 dilution staining ING4 in Formalin-fixed, Paraffin-embedded Human fetal brain tissue by Immunohistochemistry. Note nuclear staining.

Anti-ING4 antibody (ab113425)参考文献

ab113425 has not yet been referenced specifically in any publications.

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