概述

  • 产品名称Anti-ING3抗体
    参阅全部 ING3 一抗
  • 描述
    山羊多克隆抗体to ING3
  • 特异性Tested on RKO cells transfected with ING3 (although a number of other bands were seen at similar weights). The immunogen sequence is not found in isoforms 2 and 3 listed in Q9NXR8.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Chicken, Xenopus laevis
  • 免疫原

    Synthetic peptide:

    CADSRSGRKSKN

    , corresponding to amino acids 294 - 304 of Human ING3.

  • 常规说明


    ING3 is a tumor suppressor that acts as a potent growth regulator in normal and in established cells. p47 ING3 appears to modulate p53-mediated transcription, cell cycle control and apoptosis.

性能

应用

Our Abpromise guarantee covers the use of ab3713 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Predicted molecular weight: 47 kDa.

靶标

  • 相关性Function: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. Tissue specificity: Expressed in brain, heart, kidney, liver, lung, ovaries, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus. Disease: Squamous cell carcinoma of the head and neck Similarity: Belongs to the ING family. Contains 1 PHD-type zinc finger. Domain: The PHD-type zinc finger mediates the binding to H3K4me3.
  • 细胞定位Nuclear
  • 数据库链接
  • 别名
    • 1300013A07Rik antibody
    • Eaf 4 antibody
    • Eaf4 antibody
    • FLJ20089 antibody
    • ING 2 antibody
    • ING 3 antibody
    • ING2 antibody
    • ING3 antibody
    • ING3_HUMAN antibody
    • Inhibitor of growth family member 3 antibody
    • Inhibitor of growth protein 3 antibody
    • MEAF4 antibody
    • p47 ING 3 antibody
    • p47 ING3 antibody
    • p47 regulator protein antibody
    • p47ING3 antibody
    • p47ING3 protein antibody
    see all

Anti-ING3 antibody 图像

  • All lanes : Anti-ING3 antibody (ab3713) at 1/1000 dilution

    Lane 1 : RKO whole cell lysate
    Lane 2 : RKO cells transfected with ING3 - whole cell lysate

    Lysates/proteins at 10 µg per lane.

    Secondary
    IRDye 800 conjugated Rabbit anti-Goat IgG [H&L] at 1/10000 dilution

    Performed under reducing conditions.

    Predicted band size : 47 kDa
    Observed band size : 55 kDa (why is the actual band size different from the predicted?)

Anti-ING3 antibody (ab3713)参考文献

ab3713 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab3713.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"