概述

  • 产品名称Anti-ING2抗体
    参阅全部 ING2 一抗
  • 描述
    山羊多克隆抗体to ING2
  • 经测试应用适用于: WB, ICC/IFmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide: DKSTEKTKKDRRSR, corresponding to C terminal amino acids 267-280 of Human ING2.

  • 阳性对照
    • HepG2 lysate
  • 常规说明Principal Names - ING1L; inhibitor of growth family, member 1-like; p33ING2; inhibitor of growth 1-like Official Gene Symbol - ING1L GenBank Accession Number – NP_001555 LocusLink ID - 3622 (human) Gene Ontology terms - chromatin binding; signal transduction; chromosome

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab2643 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 2 - 4 µg/ml. Detects a band of approximately 33 kDa (predicted molecular weight: 32.8 kDa).Can be blocked with Human ING2 peptide (ab22925).
ICC/IF Use at an assay dependent dilution.

靶标

  • 功能Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs).
  • 组织特异性Widely expressed. Higher expressed in colon-cancer tumor than in normal colon tissues.
  • 序列相似性Belongs to the ING family.
    Contains 1 PHD-type zinc finger.
  • 结构域The PHD-type zinc finger domain binds to phosphoinositides (PtdInsPs), including phosphatidylinositol 5-phosphate (PtdIns(5)P).
  • 细胞定位Nucleus. Predominantly nuclear. Localized to chromatin and nuclear matrix. Upon reduced PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ING 1 like tumor suppressor protein antibody
    • ING 1L antibody
    • ING 2 antibody
    • ING1 like tumor suppressor protein antibody
    • ING1L antibody
    • ING1Lp antibody
    • ING2 antibody
    • ING2_HUMAN antibody
    • Inhibitor of growth 1 like antibody
    • Inhibitor of growth 1 like protein antibody
    • Inhibitor of growth 1-like protein antibody
    • Inhibitor of growth family member 1 like antibody
    • Inhibitor of growth family member 2 antibody
    • Inhibitor of growth protein 2 antibody
    • p32 antibody
    • p33 ING2 antibody
    • p33ING2 antibody
    see all

Anti-ING2 antibody 图像

Anti-ING2 antibody (ab2643)参考文献

This product has been referenced in:
  • Pedeux R  et al. ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation. Mol Cell Biol 25:6639-48 (2005). Read more (PubMed: 16024799) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab2643.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"