Anti-Influenza A Virus M2 Protein抗体[14C2] - BSA and Azide free (ab96689)

概述

  • 产品名称Anti-Influenza A Virus M2 Protein抗体[14C2] - BSA and Azide free
    参阅全部 Influenza A Virus M2 Protein 一抗
  • 描述
    小鼠单克隆抗体[14C2] to Influenza A Virus M2 Protein - BSA and Azide free
  • 种属反应性
    与反应: Influenza A
  • 免疫原

    Full length M2 protein from A/WSN/33-infected CV1 cell lysate.

  • 表位Detects the N-terminal of the Influenza A Virus M2 Protein.
  • 常规说明


    Influenza A virus is an enveloped virus encoding 10 polypeptides. RNA segment 7 encodes for two proteins: M1 (matrix 1) and M2 (matrix 2). M1 protein is encoded by an mRNA that is colinear, while M2 protein is synthesized from spliced mRNA. M2 protein is a transmembrane protein composed of three Domains: 1) 24 residues representing the N-terminal region, 2) 19 hydro-phobic residues that serve as a membrane anchor, and 3) 54 residues near the C-terminal in the cytoplasmic domain. The M2 protein has been found to play a role in Influenza replication and assembly of virion particles. Further experimentation has demonstrated that this protein is an acid-activated ion channel for virus replication.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Constituent: PBS
  • Concentration information loading...
  • 纯度Protein G purified
  • Primary antibody说明Influenza A virus is an enveloped virus encoding 10 polypeptides. RNA segment 7 encodes for two proteins: M1 (matrix 1) and M2 (matrix 2). M1 protein is encoded by an mRNA that is colinear, while M2 protein is synthesized from spliced mRNA. M2 protein is a transmembrane protein composed of three Domains: 1) 24 residues representing the N-terminal region, 2) 19 hydro-phobic residues that serve as a membrane anchor, and 3) 54 residues near the C-terminal in the cytoplasmic domain. The M2 protein has been found to play a role in Influenza replication and assembly of virion particles. Further experimentation has demonstrated that this protein is an acid-activated ion channel for virus replication.
  • 克隆单克隆
  • 克隆编号14C2
  • 同种型IgG1
  • 研究领域

靶标

  • 相关性The Matrix protein M2 forms a protons channel. When the environmental pH is lower than a threshold, the M2 channel is activated and selectively transports protons accross the membrane from the extracellular side to the cytoplasmic side. It is crucial for the uncoating process. When the virion is internalized into the endosome the channel can acidify the virion interior, promoting the dissociation of the viral matrix protein (M1) from the ribonucleoprotein (RNP) thus allowing the transport of the RNP from the virion into the cell’s nucleus. For some influenza virus subtypes, the M2 channel can elevate the intravesicular pH of the trans Golgi network, preventing the viral protein haemagglutinin, which is transported to the cell surface through the trans Golgi network, from incorrect maturation in an otherwise low pH environment.
  • 细胞定位Virion membrane. Apical cell membrane; Single-pass type III membrane protein.
  • 数据库链接
    • 别名
      • Influenza A virus matrix protein M2 antibody
      • M antibody
      • M2 antibody
      • Matrix protein 2 antibody
      • Membrane ion channel M2 antibody
      • Membrane protein M2 antibody
      • Proton channel protein M2 antibody
      see all

    Anti-Influenza A Virus M2 Protein antibody [14C2] - BSA and Azide free (ab96689)参考文献

    ab96689 has not yet been referenced specifically in any publications.

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    Finally, I have a price quote and custom made confirmation from laboratory. We are happy to provide this product at lower cost than ab5416. The price would be £194 per vial or £582 for 3 vial...

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    I just spoken to my colleague in laboratory; they have suggested that in order to justify the production cost for making it BSA and azide free at least 3 vials should be ordered. Could you let me know if you will buy ...

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    We can provide this product, BSA and azide free as a special request. Could you let me know how many vials you would like to buy?

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"