概述

  • 产品名称Anti-Importin 13抗体
    参阅全部 Importin 13 一抗
  • 描述
    兔多克隆抗体to Importin 13
  • 经测试应用适用于: WB, IP, ICC/IFmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow
  • 免疫原

    Synthetic peptide containing a sequence corresponding to a region within amino acids 901-963 (SMWIKEALQP PGFPSARLSP EQKDTFSQQI LRERVNKRRV KEMVKEFTLL CRGLHGTDYT ADY) of Human Importin 13 (NP_055467).

  • 阳性对照
    • HeLa whole cell lysate; HeLa cells

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab95993 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 108 kDa.
IP Use at 10-1 µg/mg of lysate.
ICC/IF 1/100 - 1/200.

靶标

  • 功能Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.
  • 组织特异性Expressed in fetal brain, heart, intestine and kidney.
  • 序列相似性Belongs to the importin beta family.
    Contains 14 HEAT repeats.
    Contains 1 importin N-terminal domain.
  • 细胞定位Cytoplasm. Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Imp 13 antibody
    • Imp13 antibody
    • Importin-13 antibody
    • Importin13 antibody
    • IPO 13 antibody
    • Ipo13 antibody
    • IPO13_HUMAN antibody
    • Kap 13 antibody
    • Kap13 antibody
    • Karyopherin 13 antibody
    • Karyopherin-13 antibody
    • Karyopherin13 antibody
    • KIAA0274 antibody
    • Late gestation lung 2 antibody
    • Late gestation lung 2 protein antibody
    • Lgl2 antibody
    • Ran binding protein 13 antibody
    • Ran-binding protein 13 antibody
    • RanBP 13 antibody
    • RanBP13 antibody
    see all

Anti-Importin 13 antibody 图像

  • Importin 13 was immunoprecipitated from 1 mg of HeLa whole cell lysate using 10 µg of ab95993. The precipitated Importin 13 was detected with ab95993 at 1/1000 dilution.
  • Immunofluorescence analysis of paraformaldehyde-fixed HeLa cells, using ab95993 at 1/200 dilution. Lower image is merged with DNA probe.

Anti-Importin 13 antibody (ab95993)参考文献

ab95993 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab95993.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"