概述

  • 产品名称
  • 描述
    山羊多克隆抗体to IMPDH2
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Chinese hamster
  • 免疫原

    Synthetic peptide:

    KEEEHDCFLEEI

    , corresponding to internal sequence amino acids 167-178 of Human IMPDH2 (NP_000875.2).

  • 阳性对照
    • Human Skeletal Muscle lysate.

性能

应用

Our Abpromise guarantee covers the use of ab85702 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 60 kDa (predicted molecular weight: 56 kDa).

靶标

  • 功能
    Rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors.
  • 组织特异性
    IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.
  • 通路
    Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.
  • 序列相似性
    Belongs to the IMPDH/GMPR family.
    Contains 2 CBS domains.
  • 翻译后修饰
    The N-terminus is blocked.
  • Information by UniProt
  • 数据库链接
  • 别名
    • IMDH2_HUMAN antibody
    • IMP (inosine monophosphate) dehydrogenase 2 antibody
    • IMP dehydrogenase 2 antibody
    • IMP oxireductase 2 antibody
    • IMPD 2 antibody
    • IMPD2 antibody
    • IMPDH 2 antibody
    • IMPDH II antibody
    • IMPDH-II antibody
    • Impdh2 antibody
    • Inosine 5' monophosphate dehydrogenase 2 antibody
    • Inosine 5' phosphate dehydrogenase 2 antibody
    • Inosine monophosphate dehydrogenase type II antibody
    • Inosine-5''-monophosphate dehydrogenase 2 antibody
    see all

图片

  • Anti-IMPDH2 antibody (ab85702) at 1 µg/ml + Human Skeletal Muscle lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 56 kDa
    Observed band size : 60 kDa (why is the actual band size different from the predicted?)

实验方案

文献

ab85702 has not yet been referenced specifically in any publications.

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