概述

  • 产品名称Anti-IMPDH1抗体
    参阅全部 IMPDH1 一抗
  • 描述
    兔多克隆抗体to IMPDH1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 83-113 of Human IMPDH1 (NP_001136045.1, NP_899066.1, NP_001096075.1).

  • 阳性对照
    • HL60 cell line lysate

性能

应用

Our Abpromise guarantee covers the use of ab123647 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 55 kDa.

靶标

  • 功能Rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors.
  • 组织特异性IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.
  • 通路Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.
  • 疾病相关Defects in IMPDH1 are the cause of retinitis pigmentosa type 10 (RP10) [MIM:180105]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP10 inheritance is autosomal dominant.
  • 序列相似性Belongs to the IMPDH/GMPR family.
    Contains 2 CBS domains.
  • Information by UniProt
  • 数据库链接
  • 别名
    • IMDH1_HUMAN antibody
    • IMP (inosine monophosphate) dehydrogenase 1 antibody
    • IMP dehydrogenase 1 antibody
    • IMPD 1 antibody
    • IMPD antibody
    • IMPD1 antibody
    • IMPDH 1 antibody
    • IMPDH I antibody
    • IMPDH-I antibody
    • Impdh1 antibody
    • Inosine 5' monophosphate dehydrogenase 1 antibody
    • Inosine monophosphate dehydrogenase 1 antibody
    • Inosine-5''-monophosphate dehydrogenase 1 antibody
    • LCA11 antibody
    • RP10 antibody
    • sWSS2608 antibody
    see all

Anti-IMPDH1 antibody 图像

  • Anti-IMPDH1 antibody (ab123647) at 1/100 dilution + HL60 cell line lysate at 35 µg

    Predicted band size : 55 kDa

Anti-IMPDH1 antibody (ab123647)参考文献

ab123647 has not yet been referenced specifically in any publications.

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