概述

  • 产品名称Anti-ILP2抗体
    参阅全部 ILP2 一抗
  • 描述
    兔多克隆抗体to ILP2
  • 经测试应用适用于: ICC/IF, WB, ICCmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide:

    TGYEARLITFGT

    , corresponding to amino acids 2-13 of Human ILP2. (Peptide available as ab9665.)

  • 阳性对照
    • Human HepG2 or MOLT4 cell lysate
  • 常规说明


    Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP that bind to and inhibits specific proteases. A novel member in the IAP protein family was recently identified and designated ILP-2 for IAP-like protein-2 (1). ILP-2 has high homology to ILP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues (1). ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibits apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9. These results suggest that ILP-2 is a novel IAP family member with restricted specificity for caspase-9.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液PBS with 0.02% sodium azide
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • Primary antibody说明Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP that bind to and inhibits specific proteases. A novel member in the IAP protein family was recently identified and designated ILP-2 for IAP-like protein-2 (1). ILP-2 has high homology to ILP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues (1). ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibits apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9. These results suggest that ILP-2 is a novel IAP family member with restricted specificity for caspase-9.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab9664 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 33 kDa.Can be blocked with Human ILP2 peptide (ab9665).
ICC Use a concentration of 10 µg/ml.

靶标

  • 功能Protects against apoptosis mediated by BAX.
  • 组织特异性Testis specific in normal tissues.
  • 序列相似性Belongs to the IAP family.
    Contains 1 BIR repeat.
    Contains 1 RING-type zinc finger.
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Baculoviral IAP repeat containing 8 antibody
    • Baculoviral IAP repeat containing protein 8 antibody
    • Baculoviral IAP repeat-containing protein 8 antibody
    • BIRC 8 antibody
    • BIRC8 antibody
    • BIRC8 protein antibody
    • BIRC8_HUMAN antibody
    • hILP 2 antibody
    • hILP2 antibody
    • IAP like protein 2 antibody
    • IAP-like protein 2 antibody
    • ILP 2 antibody
    • ILP-2 antibody
    • Inhibitor of apoptosis like protein 2 antibody
    • Inhibitor of apoptosis-like protein 2 antibody
    • Testis specific inhibitor of apoptosis antibody
    • Testis-specific inhibitor of apoptosis antibody
    see all

Anti-ILP2 antibody 图像

  • Western blot analysis of ILP-2 expression in human HepG2 (lane 1) and MOLT4 (lane 2) cell lysates and mouse spleen (lane 3) tissue lysates with anti-ILP-2 at 1 µg/ml.
  • ab9664 at 10µg/ml staining ILP2 in HepG2 cells by Immunocytochemistry.

Anti-ILP2 antibody (ab9664)参考文献

ab9664 has not yet been referenced specifically in any publications.

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