概述

  • 产品名称Anti-IL6R抗体[B-F19]
    参阅全部 IL6R 一抗
  • 描述
    小鼠单克隆抗体[B-F19] to IL6R
  • 特异性This antibody is specific for IL6R. (Recognises both soluble and membrane bound IL6R)
  • 经测试应用适用于: Flow Cytmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    IL6R transfected CHO cell line.

性能

应用

Our Abpromise guarantee covers the use of ab27405 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt
  • 应用说明Flow Cyt: Use at an assay dependent dilution.

    Blocks IL6 induced proliferation of XG-1 cell line.
    Blocks IL6 binding to its receptor.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.
      Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.
    • 组织特异性Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum.
    • 序列相似性Belongs to the type I cytokine receptor family. Type 3 subfamily.
      Contains 1 fibronectin type-III domain.
      Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    • 结构域The two fibronectin type-III-like domains, contained in the N-terminal part, form together a cytokine-binding domain.
      The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    • 翻译后修饰A short soluble form may also be released from the membrane by proteolysis.
    • 细胞定位Secreted and Basolateral cell membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CD 126 antibody
      • CD126 antibody
      • CD126 antigen antibody
      • gp80 antibody
      • IL 6R 1 antibody
      • IL 6R alpha antibody
      • IL 6R antibody
      • IL-6 receptor alpha chain antibody
      • IL-6 receptor subunit alpha antibody
      • IL-6R 1 antibody
      • IL-6R subunit alpha antibody
      • IL-6R-alpha antibody
      • IL-6RA antibody
      • IL6Q antibody
      • Il6r antibody
      • IL6RA antibody
      • IL6RA_HUMAN antibody
      • IL6RQ antibody
      • Interleukin 6 receptor antibody
      • interleukin 6 receptor, alpha antibody
      • Interleukin-6 receptor subunit alpha antibody
      • Membrane glycoprotein 80 antibody
      • MGC30256 antibody
      see all

    Anti-IL6R antibody [B-F19] 图像

    • Ab27405, staining IL6R by FACS.

    Anti-IL6R antibody [B-F19] (ab27405)参考文献

    This product has been referenced in:
    • Larregina AT  et al. Pattern of cytokine receptors expressed by human dendritic cells migrated from dermal explants. Immunology 91:303-13 (1997). Read more (PubMed: 9227332) »

    See 1 Publication for this product

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