Anti-IL6R抗体(ab85105)

概述

  • 产品名称Anti-IL6R抗体
    参阅全部 IL6R 一抗
  • 描述
    兔多克隆抗体to IL6R
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    A 16 amino acid peptide from near the intermediate residues of Human IL6R protein (NM_000565.2)

  • 阳性对照
    • Jurkat cell lysate, 803 cell lysate.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab85105 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/200 - 1/500. Detects a band of approximately 60 kDa (predicted molecular weight: 52 kDa).

靶标

  • 功能Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.
    Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.
  • 组织特异性Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum.
  • 序列相似性Belongs to the type I cytokine receptor family. Type 3 subfamily.
    Contains 1 fibronectin type-III domain.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • 结构域The two fibronectin type-III-like domains, contained in the N-terminal part, form together a cytokine-binding domain.
    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • 翻译后修饰A short soluble form may also be released from the membrane by proteolysis.
  • 细胞定位Secreted and Basolateral cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CD 126 antibody
    • CD126 antibody
    • CD126 antigen antibody
    • gp80 antibody
    • IL 6R 1 antibody
    • IL 6R alpha antibody
    • IL 6R antibody
    • IL-6 receptor alpha chain antibody
    • IL-6 receptor subunit alpha antibody
    • IL-6R 1 antibody
    • IL-6R subunit alpha antibody
    • IL-6R-alpha antibody
    • IL-6RA antibody
    • IL6Q antibody
    • Il6r antibody
    • IL6RA antibody
    • IL6RA_HUMAN antibody
    • IL6RQ antibody
    • Interleukin 6 receptor antibody
    • interleukin 6 receptor, alpha antibody
    • Interleukin-6 receptor subunit alpha antibody
    • Membrane glycoprotein 80 antibody
    • MGC30256 antibody
    see all

Anti-IL6R antibody 图像

Anti-IL6R antibody (ab85105)参考文献

ab85105 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your call yesterday and for your patience while I have been in touch with the lab regarding ab85105.



The antibody has also been tested with fetal liver lysate, which was also positive with the antibody. At this time w...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"