概述

  • 产品名称
  • 描述
    兔多克隆抗体to IL37
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 45-208 of Human IL1F7 (AAH20637).

  • 阳性对照
    • A431 whole cell lysate; 293T and Raji cell lysates

性能

应用

Our Abpromise guarantee covers the use of ab101376 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 24 kDa.

靶标

  • 功能
    Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation.
  • 组织特异性
    In general, low constitutive expression, if any, in healthy tissues; high expression in inflammatory counterparts, including in synovial tissues from individuals with active rheumatoid arthritis. Isoform A, isoform B and isoform C are expressed in testis, colon, placenta, lung and lymph node. Isoform D and isoform E were found only in testis and bone marrow. Whereas only isoform A is found in brain, only isoform B in kidney and only isoform C in heart.
  • 序列相似性
    Belongs to the IL-1 family.
  • 翻译后修饰
    Proteolytically converted to the mature form by CASP1.
  • 细胞定位
    Cytoplasm > cytosol. Nucleus. Secreted. Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions. Only the CASP1-cleaved mature form translocates into the nucleus upon LPS stimulation.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FIL1 antibody
    • FIL1 zeta antibody
    • FIL1(ZETA) antibody
    • FIL1Z antibody
    • IL 1 zeta antibody
    • IL 1F7 antibody
    • IL 1F7b (IL 1H4, IL 1H, IL 1RP1) antibody
    • IL 1H4 antibody
    • IL 1RP1 antibody
    • IL 1X antibody
    • IL 1X protein antibody
    • IL-1 zeta antibody
    • IL-1F7 antibody
    • IL-1H antibody
    • IL-1H4 antibody
    • IL-1RP1 antibody
    • IL-1X antibody
    • IL-37 antibody
    • IL1F7 (canonical product IL 1F7b) antibody
    • IL1F7 antibody
    • IL1F7_HUMAN antibody
    • IL1H4 antibody
    • IL1RP1 antibody
    • Interleukin 1 family member 7 antibody
    • interleukin 1 family, member 7 (zeta) antibody
    • Interleukin 1 homolog 4 antibody
    • Interleukin 1 related protein antibody
    • Interleukin 1 superfamily z antibody
    • Interleukin 1 zeta antibody
    • Interleukin 37 antibody
    • Interleukin-1 family member 7 antibody
    • Interleukin-1 homolog 4 antibody
    • Interleukin-1 zeta antibody
    • Interleukin-1-related protein antibody
    • Interleukin-23 antibody
    see all

Anti-IL37 antibody 图像

  • Anti-IL37 antibody (ab101376) at 1/1000 dilution + A431 whole cell lysate at 30 µg

    Predicted band size : 24 kDa

实验方案

Anti-IL37 antibody (ab101376)参考文献

This product has been referenced in:
  • Ge G  et al. Interleukin-37 suppresses tumor growth through inhibition of angiogenesis in non-small cell lung cancer. J Exp Clin Cancer Res 35:13 (2016). WB . Read more (PubMed: 26791086) »

See 1 Publication for this product

Product Wall

Hello! The MW of the isoforms of IL37 are as follows:

Isoform A 21 kD

Isoform C 19 kD

Isofrm D 22 kD

Isofrm E 17 kD

For your convenience we do have links on our datasheet that can connect you to resourc...

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Thank you for contacting us. Based on the immunogen sequence the antibody should detect all 5 isoforms.

I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

Use ou...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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