概述

  • 产品名称Anti-IL33抗体
    参阅全部 IL33 一抗
  • 描述
    兔多克隆抗体to IL33
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length Human protein.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 0.15M Sodium chloride, 0.02M Potassium phosphate, pH 7.2
  • Concentration information loading...
  • 纯度IgG fraction
  • 纯化说明The purified antibody has been heated to 56°C for 30 minutes. Endotoxin content is estimated to be <10 pg/ml by the LAL method.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab92822 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
  • 应用说明ELISA: 1/20000 - 1/100000.
    WB: 1/500 - 1/2000. Predicted molecular weight: 31 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528).
      In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (PubMed:21734074). This form is rapidely lost upon angiogenic or proinflammatory activation (PubMed:18787100).
    • 组织特异性Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta.
    • 序列相似性Belongs to the IL-1 family. Highly divergent.
    • 结构域The homeodomain-like HTH domain mediates nuclear localization and heterochromatin association.
    • 翻译后修饰The full length protein can be released from cells and is able to signal via the IL1RL1/ST2 receptor. However, proteolytic processing by CSTG/cathepsin G and ELANE/neutrophil elastase produces C-terminal peptides that are more active than the unprocessed full length protein. May also be proteolytically processed by calpains (PubMed:19596270). Proteolytic cleavage mediated by apoptotic caspases including CASP3 and CASP7 results in IL33 inactivation (PubMed:19559631). In vitro proteolytic cleavage by CASP1 was reported (PubMed:16286016) but could not be confirmed in vivo (PubMed:19465481) suggesting that IL33 is probably not a direct substrate for that caspase.
    • 细胞定位Nucleus. Chromosome. Cytoplasmic vesicle, secretory vesicle. Secreted. Associates with heterochromatin and mitotic chromosomes (PubMed:17185418).
    • Information by UniProt
    • 数据库链接
    • 别名
      • C9orf26 antibody
      • CHROMOSOME 9 OPEN READING FRAME 26 antibody
      • DKFZp586H0523 antibody
      • DVS27 antibody
      • DVS27 related protein antibody
      • IL 1F11 antibody
      • IL 33 antibody
      • IL-1F11 antibody
      • IL-33 antibody
      • IL1F11 antibody
      • IL33 antibody
      • IL33_HUMAN antibody
      • Interleukin 1 family member 11 antibody
      • Interleukin 33 antibody
      • INTERLEUKIN 33 NFHEV antibody
      • Interleukin 33 precursor antibody
      • Interleukin-1 family member 11 antibody
      • Interleukin-33 (109-270) antibody
      • Interleukin33 antibody
      • NF HEV antibody
      • NF-HEV antibody
      • NFEHEV antibody
      • NFHEV antibody
      • Nuclear factor for high endothelial venules antibody
      • Nuclear factor from high endothelial venules antibody
      • OTTHUMP00000021041 antibody
      • RP11 575C20.2 antibody
      see all

    Anti-IL33 antibody 图像

    • Anti-IL33 antibody (ab92822) + Recombinant human IL33 (100-145)

      Predicted band size : 31 kDa

    Anti-IL33 antibody (ab92822)参考文献

    ab92822 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab92822.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"