Anti-IL23 Receptor抗体[RM0110-6D34] (ab86640)


  • 产品名称Anti-IL23 Receptor抗体[RM0110-6D34]
    参阅全部 IL23 Receptor 一抗
  • 描述
    大鼠单克隆抗体[RM0110-6D34] to IL23 Receptor
  • 特异性This antibody detects mouse IL23 Receptor in Western blotting.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Mouse recombinant protein of the extracellular domain of IL23 Receptor.



Our Abpromise guarantee covers the use of ab86640 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 72 kDa.


  • 功能Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
  • 组织特异性Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells.
  • 疾病相关Genetic variations in IL23R are associated with inflammatory bowel disease type 17 (IBD17) [MIM:612261]. IBD17 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
    Genetic variations in IL23R are a cause of susceptibility to psoriasis type 7 (PSORS7) [MIM:605606]. Psoriasis is a common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.
  • 序列相似性Belongs to the type I cytokine receptor family. Type 2 subfamily.
    Contains 2 fibronectin type-III domains.
  • 翻译后修饰Phosphorylated in response to IL23.
  • 细胞定位Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • IL 23R antibody
    • IL-23 receptor antibody
    • IL-23R antibody
    • Il23r antibody
    • IL23R_HUMAN antibody
    • Interleukin 23 receptor antibody
    • Interleukin-23 receptor antibody
    see all

Anti-IL23 Receptor antibody [RM0110-6D34] (ab86640)参考文献

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