概述

  • 产品名称Anti-IL23 Receptor抗体
    参阅全部 IL23 Receptor 一抗
  • 描述
    兔多克隆抗体to IL23 Receptor
  • 特异性Based on immunogen sequence, this antibody will recognize the 629 AA, 390 AA and 227 AA forms of human IL-23R.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide:

    IPNMKNSNVVKMLQENSELMNNNSSEQVLYVDPMITEIKEIFIPEHKPTD YKKENTGPLETRDYPQNSLFD

    , corresponding to amino acids 400-470 of Human IL23 Receptor.

  • 阳性对照
    • Jurkat and NIH3T3 cells

性能

应用

Our Abpromise guarantee covers the use of ab22059 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500. Detects a band of approximately 72 kDa (predicted molecular weight: 72 kDa).

靶标

  • 功能Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
  • 组织特异性Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells.
  • 疾病相关Genetic variations in IL23R are associated with inflammatory bowel disease type 17 (IBD17) [MIM:612261]. IBD17 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
    Genetic variations in IL23R are a cause of susceptibility to psoriasis type 7 (PSORS7) [MIM:605606]. Psoriasis is a common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.
  • 序列相似性Belongs to the type I cytokine receptor family. Type 2 subfamily.
    Contains 2 fibronectin type-III domains.
  • 翻译后修饰Phosphorylated in response to IL23.
  • 细胞定位Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • IL 23R antibody
    • IL-23 receptor antibody
    • IL-23R antibody
    • Il23r antibody
    • IL23R_HUMAN antibody
    • Interleukin 23 receptor antibody
    • Interleukin-23 receptor antibody
    see all

Anti-IL23 Receptor antibody 图像

  • All lanes : Anti-IL23 Receptor antibody (ab22059) at 1 µg/ml

    Lane 1 : Human colon tissue lysate - total protein (ab30051)
    Lane 2 : Mouse colon tissue lysate - total protein (ab29544)
    Lane 3 : Human spleen tissue lysate - total protein (ab29699)
    Lane 4 : Mouse spleen tissue lysate - total protein (ab29293)
    Lane 5 : A431 (Human epithelial carcinoma cell line) Whole Cell Lysate
    Lane 6 : Hela Whole Cell Lysate - Staurosporine Treated (24hr, 500nM)
    Lane 7 : NIH 3T3 whole cell lysate (ab7179)
    Lane 8 : Liver (Mouse) Tissue Lysate

    Secondary
    Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 72 kDa


    Exposure time : 8 minutes

Anti-IL23 Receptor antibody (ab22059)参考文献

This product has been referenced in:
  • Zwiers A  et al. Cutting Edge: A Variant of the IL-23R Gene Associated with Inflammatory Bowel Disease Induces Loss of MicroRNA Regulation and Enhanced Protein Production. J Immunol 188:1573-7 (2012). WB ; Human . Read more (PubMed: 22262659) »

See 1 Publication for this product

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