The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500. Detects a band of approximately 72 kDa (predicted molecular weight: 72 kDa).
功能Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
组织特异性Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells.
疾病相关Genetic variations in IL23R are associated with inflammatory bowel disease type 17 (IBD17) [MIM:612261]. IBD17 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Genetic variations in IL23R are a cause of susceptibility to psoriasis type 7 (PSORS7) [MIM:605606]. Psoriasis is a common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.
序列相似性Belongs to the type I cytokine receptor family. Type 2 subfamily. Contains 2 fibronectin type-III domains.
All lanes : Anti-IL23 Receptor antibody (ab22059) at 1 µg/ml
Lane 1 : Human colon tissue lysate - total protein (ab30051) Lane 2 : Mouse colon tissue lysate - total protein (ab29544) Lane 3 : Human spleen tissue lysate - total protein (ab29699) Lane 4 : Mouse spleen tissue lysate - total protein (ab29293) Lane 5 : A431 (Human epithelial carcinoma cell line) Whole Cell Lysate Lane 6 : Hela Whole Cell Lysate - Staurosporine Treated (24hr, 500nM) Lane 7 : NIH 3T3 whole cell lysate (ab7179) Lane 8 : Liver (Mouse) Tissue Lysate
Secondary Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution Developed using the ECL technique
Performed under reducing conditions.
Predicted band size : 72 kDa
Exposure time : 8 minutes
Anti-IL23 Receptor antibody (ab22059)参考文献
This product has been referenced in:
Zwiers A et al. Cutting Edge: A Variant of the IL-23R Gene Associated with Inflammatory Bowel Disease Induces Loss of MicroRNA Regulation and Enhanced Protein Production. J Immunol188:1573-7 (2012).
Read more (PubMed: 22262659) »