概述

  • 产品名称
    Anti-IL23抗体[G23-8]
    参阅全部 IL23 一抗
  • 描述
    大鼠单克隆抗体[G23-8] to IL23
  • 特异性
    ab91271 reacts with the p19 subunit of IL23.
  • 经测试应用
    适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Recombinant fragment corresponding to IL23.

  • 阳性对照
    • Recombinant Mouse IL23

性能

应用

Our Abpromise guarantee covers the use of ab91271 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use a concentration of 1 - 4 µg/ml. TMB, rather than ABTS, should be used as a substrate to achieve the optimum sensitivity.
WB Use at an assay dependent concentration. Predicted molecular weight: 21 kDa.

靶标

  • 功能
    Associates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
  • 组织特异性
    Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).
  • 序列相似性
    Belongs to the IL-6 superfamily.
  • 发展阶段
    Expressed by newborns dendritic cells.
  • 细胞定位
    Secreted. Secreted upon association with IL12B.
  • Information by UniProt
  • 数据库链接
  • 别名
    • IL 23 A antibody
    • IL 23 antibody
    • IL 23 subunit alpha antibody
    • IL 23A antibody
    • IL 23p19 antibody
    • IL-23 subunit alpha antibody
    • IL-23-A antibody
    • IL-23p19 antibody
    • IL12B antibody
    • IL23 antibody
    • Il23a antibody
    • IL23A_HUMAN antibody
    • IL23P19 antibody
    • interleukin 12B antibody
    • Interleukin 23 alpha subunit p19 antibody
    • Interleukin 23 p19 subunit antibody
    • interleukin 23 subunit alpha antibody
    • interleukin 23 subunit p19 antibody
    • interleukin six, G CSF related factor antibody
    • Interleukin-23 subunit alpha antibody
    • Interleukin-23 subunit p19 antibody
    • JKA3 induced upon T cell activation antibody
    • MGC79388 antibody
    • P19 antibody
    • SGRF antibody
    see all

实验方案

Anti-IL23 antibody [G23-8] (ab91271)参考文献

This product has been referenced in:

See 1 Publication for this product

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