The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
功能This is a receptor for interleukin-21.
组织特异性Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen.
序列相似性Belongs to the type I cytokine receptor family. Type 4 subfamily. Contains 2 fibronectin type-III domains.
结构域The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation.
翻译后修饰C-mannosylated at Trp-214 in the WSXWS motif, the sugar chain makes extensive hydrogen bonds with Asn-73 sugar, and bridges the two fibronectin domains transforming the V-shaped receptor into an A-frame.