概述

  • 产品名称Anti-IL1RAPL1抗体
    参阅全部 IL1RAPL1 一抗
  • 描述
    小鼠单克隆抗体to IL1RAPL1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Recombinant fragment: FEKAELSKSK EISCRDIEDF LLPTREPEIL WYKECRTKTW RPSIVFKRDT LLIREVREDD IGNYTCELKY GGFVVRRTTE LTVTAPLTDK PPKLLYPMES , corresponding to amino acids 151-251 of Human IL1RAPL1

性能

应用

Our Abpromise guarantee covers the use of ab56961 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK.
    • 组织特异性Detected at low levels in heart, skeletal muscle, ovary, skin, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. Detected at very low levels in tonsil, prostate, testis, small intestine, placenta, colon and fetal liver.
    • 疾病相关Defects in IL1RAPL1 are the cause of mental retardation X-linked type 21 (MRX21) [MIM:300143]. Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.
    • 序列相似性Belongs to the interleukin-1 receptor family.
      Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
      Contains 1 TIR domain.
    • 细胞定位Cell membrane. Cytoplasm. May localize to the cell body and growth cones of dendrite-like processes.
    • Information by UniProt
    • 数据库链接
    • 别名
      • IL 1 RAPL 1 antibody
      • IL 1RAPL 1 antibody
      • IL-1-RAPL-1 antibody
      • IL-1RAPL-1 antibody
      • IL1R8 antibody
      • IL1RAPL 1 antibody
      • IL1RAPL antibody
      • IL1RAPL-1 antibody
      • IL1RAPL1 antibody
      • Interleukin 1 receptor 8 antibody
      • Interleukin 1 receptor accessory protein like 1 antibody
      • Interleukin-1 receptor accessory protein-like 1 antibody
      • IRPL1_HUMAN antibody
      • Mental retardation X linked 10 antibody
      • Mental retardation X linked 21 antibody
      • Mental retardation X linked 34 antibody
      • MRX 21 antibody
      • MRX 34 antibody
      • MRX10 antibody
      • MRX21 antibody
      • MRX34 antibody
      • Oligophrenin 4 antibody
      • Oligophrenin-4 antibody
      • Oligophrenin4 antibody
      • OPHN 4 antibody
      • OPHN4 antibody
      • Three immunoglobulin domain containing IL 1 receptor related 2 antibody
      • Three immunoglobulin domain-containing IL-1 receptor-related 2 antibody
      • TIGIRR 2 antibody
      • TIGIRR-2 antibody
      • TIGIRR2 antibody
      • X linked interleukin 1 receptor accessory protein like 1 antibody
      • X-linked interleukin-1 receptor accessory protein-like 1 antibody
      see all

    Anti-IL1RAPL1 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab56961 IL1RAPL1 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    Anti-IL1RAPL1 antibody (ab56961)参考文献

    This product has been referenced in:
    • Handley MT  et al. Structural and functional deficits in a neuronal calcium sensor-1 mutant identified in a case of autistic spectrum disorder. PLoS One 5:e10534 (2010). WB ; Mouse . Read more (PubMed: 20479890) »

    See 1 Publication for this product

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