Anti-IL-17RC抗体(ab69673)
Key features and details
- Mouse polyclonal to IL-17RC
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-IL-17RC抗体
参阅全部 IL-17RC 一抗 -
描述
小鼠多克隆抗体to IL-17RC -
宿主
Mouse -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human -
免疫原
Recombinant full length protein within Human IL-17RC aa 1-550. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
Database link: AAH06411.1 -
阳性对照
- IL17RC transfected 293T cell lysate.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.40
Constituent: 100% PBS -
Concentration information loading...
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纯度
Protein G purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab69673于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
说明 |
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WB: 1/500 - 1/1000. Predicted molecular weight: 86 kDa (SwissProt isoform 1).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
靶标
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相关性
IL-17RC is a single pass transmembrane protein that shares limited similarity with the interleukin 17 receptor. It is widely expressed in non leukocyte tissues and forms a heteromeric receptor for IL-17 with IL-17RA. At least four different isoforms are known to exist. -
细胞定位
Cell membrane; Single pass type I membrane protein. Note: soluble isoforms may be produced. -
数据库链接
- Entrez Gene: 84818 Human
- Omim: 610925 Human
- SwissProt: Human
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别名
- IL 17 receptor C antibody
- IL 17RC antibody
- IL 17RL antibody
see all
图片
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All lanes : Anti-IL-17RC antibody (ab69673) at 1/500 dilution
Lane 1 : IL17RC transfected 293T cell lysate
Lane 2 : Non transfected 293T cell lysate
Lysates/proteins at 25 µg per lane.
Secondary
All lanes : Goat Anti-Mouse IgG (H&L)-HRP conjugated at 1/2500 dilution
Predicted band size: 86 kDa
Observed band size: 70 kDa why is the actual band size different from the predicted?
数据表及文件
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Datasheet download
文献 (6)
ab69673 被引用在 6 文献中.
- Janiczek M et al. Expression Levels of IL-17A, IL-17F, IL-17RA, and IL-17RC in Prostate Cancer with Taking into Account the Histological Grade according to Gleason Scale in Comparison to Benign Prostatic Hyperplasia: In Search of New Therapeutic Options. J Immunol Res 2020:4910595 (2020). PubMed: 32537467
- Crawford MP et al. CD4 T cell-intrinsic role for the T helper 17 signature cytokine IL-17: Effector resistance to immune suppression. Proc Natl Acad Sci U S A 117:19408-19414 (2020). PubMed: 32719138
- Wang P et al. Potential role of the IL17RC gene in the thoracic ossification of the posterior longitudinal ligament. Int J Mol Med 43:2005-2014 (2019). PubMed: 30864693
- Wang P et al. IL17RC affects the predisposition to thoracic ossification of the posterior longitudinal ligament. J Orthop Surg Res 14:210 (2019). PubMed: 31291973
- Roussel L et al. IL-17 promotes p38 MAPK-dependent endothelial activation enhancing neutrophil recruitment to sites of inflammation. J Immunol 184:4531-7 (2010). IHC-P ; Human . PubMed: 20228195
- Roussel L & Rousseau S IL-17 primes airway epithelial cells lacking functional Cystic Fibrosis Transmembrane conductance Regulator (CFTR) to increase NOD1 responses. Biochem Biophys Res Commun 391:505-9 (2010). IHC-P ; Human . PubMed: 19931506