概述

  • 产品名称Anti-IL17F抗体
    参阅全部 IL17F 一抗
  • 描述
    兔多克隆抗体to IL17F
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 50 - 150 of Human IL17F.

    (Peptide available as ab108478.)

  • 阳性对照
    • This antibody gave a positive signal in the following whole cell lysates: Jurkat; HL60.

性能

应用

Our Abpromise guarantee covers the use of ab95340 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 15, 17 kDa (predicted molecular weight: 18 kDa).

靶标

  • 功能Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover (PubMed:11591732, PubMed:11591768, PubMed:11574464). Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (PubMed:11591732). Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation.
  • 组织特异性Expressed in activated, but not resting, CD4+ T-cells and activated monocytes.
  • 疾病相关Candidiasis, familial, 6
  • 序列相似性Belongs to the IL-17 family.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CANDF6 antibody
    • Cytokine ML 1 antibody
    • Cytokine ML-1 antibody
    • IL 17F antibody
    • IL 24 antibody
    • IL-17F antibody
    • Il17f antibody
    • IL17F_HUMAN antibody
    • Interleukin 17F antibody
    • Interleukin 24 antibody
    • Interleukin-17F antibody
    • ML 1 antibody
    • ML1 antibody
    • Mutant IL 17F antibody
    • OTTHUMP00000016602 antibody
    see all

Anti-IL17F antibody 图像

  • All lanes : Anti-IL17F antibody (ab95340) at 1 µg/ml

    Lane 1 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate
    Lane 2 : HL60 (Human promyelocytic leukemia cell line) Whole Cell Lysate
    Lane 3 : LPS-Treated HL60 Whole Cell Lysate

    Lysates/proteins at 10 µg per lane.

    Secondary
    Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 18 kDa
    Observed band size : 15,17 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 100 kDa,150 kDa,60 kDa,75 kDa. We are unsure as to the identity of these extra bands.

    Exposure time : 16 minutes

Anti-IL17F antibody (ab95340)参考文献

ab95340 has not yet been referenced specifically in any publications.

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