Anti-IL-17RA Receptor抗体[RM0104-10B27] (ab86487)
Key features and details
- Rat monoclonal [RM0104-10B27] to IL-17RA Receptor
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG2
概述
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产品名称
Anti-IL-17RA Receptor抗体[RM0104-10B27]
参阅全部 IL-17RA Receptor 一抗 -
描述
大鼠单克隆抗体[RM0104-10B27] to IL-17RA Receptor -
宿主
Rat -
特异性
This antibody detects mouse IL17A Receptor in Western blotting, but not IL17B Receptor.
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经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse -
免疫原
Recombinant fragment corresponding to Mouse IL-17RA Receptor (extracellular).
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
存储溶液
Constituent: PBS -
Concentration information loading...
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纯度
Protein A purified -
纯化说明
The IgG fraction of culture supernatant was purified by Protein A affinity chromatography. -
克隆
单克隆 -
克隆编号
RM0104-10B27 -
同种型
IgG2 -
研究领域
相关产品
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Compatible Secondaries
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab86487于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
WB |
Use at an assay dependent concentration.
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说明 |
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WB
Use at an assay dependent concentration. |
靶标
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功能
Receptor for IL17A and IL17F. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling. -
组织特异性
Widely expressed. -
疾病相关
Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5) [MIM:613953]. CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. -
序列相似性
Contains 1 SEFIR domain. -
翻译后修饰
Glycosylated. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 16172 Mouse
- SwissProt: Q60943 Mouse
- Unigene: 4481 Mouse
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别名
- CANDF5 antibody
- CD217 antibody
- CD217 antigen antibody
see all
数据表及文件
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Datasheet download
文献 (1)
ab86487 被引用在 1 文献中.
- Deguise MO et al. Differential induction of muscle atrophy pathways in two mouse models of spinal muscular atrophy. Sci Rep 6:28846 (2016). WB . PubMed: 27349908